Contents
Vol 6, Issue 231
Contents
Focus
- Noninvasive Prenatal Testing Goes Global
Noninvasive prenatal genetic testing is becoming available worldwide, but many practical and ethical challenges in the developing world should be considered.
Research Articles
- Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance
Fibrosis resolution is impaired by aging and is mediated by altered cellular redox homeostasis because of a Nox4-Nrf2 imbalance that promotes an apoptosis-resistant myofibroblast phenotype.
- Sustained Normalization of Neurological Disease after Intracranial Gene Therapy in a Feline Model
In a feline model of lysosomal storage disease, intracranial gene therapy achieved therapeutic efficacy in the CNS and increased long-term survival.
- Immunological Visibility: Posttranscriptional Regulation of Human NKG2D Ligands by the EGF Receptor Pathway
Environmental changes induce human NKG2D ligand expression—immunological visibility—through the EGFR stress response.
Editors' Choice
- The GRM Face of Chondromyxoid Fibroma
Whole-genome sequencing of chondromyxoid fibromas identified up-regulation of a glutamate receptor–encoding gene as a specific driver of tumorigenesis.
- The Chicken or the Egg? Checkpoint Markers Identify Tumor-Specific T Cells in Melanoma
Surface expression of inhibitory receptors such as PD-1 identifies the tumor antigen-specific CD8+ T cells that infiltrate melanoma.
- A Marker for Concussion?
Total tau protein concentrations in blood correlate with clinical symptoms of concussion in ice hockey players.
- How Can I Recover if You Won’t Let Me Sleep?
In a mouse model of myocardial infarction, a 5-day period of diurnal disruption led to impaired cardiac healing after myocardial infarction.
