Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

Vladimir M. Liarski; Natalya Kaverina; Anthony Chang; Daniel Brandt; Denisse Yanez; Lauren Talasnik; Gianluca Carlesso; Ronald Herbst; Tammy O. Utset; Christine Labno; Yahui Peng; Yulei Jiang; Maryellen L. Giger; Marcus R. Clark

doi:10.1126/scitranslmed.3008146

Research ArticleInflammation

Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

Vladimir M. Liarski¹,
Natalya Kaverina¹,
Anthony Chang²,
Daniel Brandt¹,
Denisse Yanez¹,
Lauren Talasnik²,
Gianluca Carlesso³,
Ronald Herbst³,
Tammy O. Utset¹,
Christine Labno⁴,
Yahui Peng⁵,
Yulei Jiang⁵,
Maryellen L. Giger⁵ and
Marcus R. Clark¹,*

¹Section of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.
²Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
³MedImmune, LLC, Department of Respiratory, Inflammation and Autoimmunity, One MedImmune Way, Gaithersburg, MD 20878, USA.
⁴Integrated Microscopy Core Facility, Office of Shared Research Facilities, University of Chicago, Chicago, IL 60637, USA.
⁵Department of Radiology, University of Chicago, Chicago, IL 60637, USA.

↵*Corresponding author. E-mail: mclark{at}medicine.bsd.uchicago.edu

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Science Translational Medicine 02 Apr 2014:
Vol. 6, Issue 230, pp. 230ra46
DOI: 10.1126/scitranslmed.3008146

Vladimir M. Liarski

1Section of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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Natalya Kaverina

1Section of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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Anthony Chang

2Department of Pathology, University of Chicago, Chicago, IL 60637, USA.

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Daniel Brandt

1Section of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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Denisse Yanez

1Section of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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Lauren Talasnik

2Department of Pathology, University of Chicago, Chicago, IL 60637, USA.

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Gianluca Carlesso

3MedImmune, LLC, Department of Respiratory, Inflammation and Autoimmunity, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Ronald Herbst

3MedImmune, LLC, Department of Respiratory, Inflammation and Autoimmunity, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Tammy O. Utset

1Section of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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Christine Labno

4Integrated Microscopy Core Facility, Office of Shared Research Facilities, University of Chicago, Chicago, IL 60637, USA.

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Yahui Peng

5Department of Radiology, University of Chicago, Chicago, IL 60637, USA.

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Yulei Jiang

5Department of Radiology, University of Chicago, Chicago, IL 60637, USA.

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Maryellen L. Giger

5Department of Radiology, University of Chicago, Chicago, IL 60637, USA.

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Marcus R. Clark

1Section of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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For correspondence: mclark@medicine.bsd.uchicago.edu

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Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

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