IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

Sarah L. Doyle; Ema Ozaki; Kiva Brennan; Marian M. Humphries; Kelly Mulfaul; James Keaney; Paul F. Kenna; Arvydas Maminishkis; Anna-Sophia Kiang; Sean P. Saunders; Emily Hams; Ed C. Lavelle; Clair Gardiner; Padraic G. Fallon; Peter Adamson; Peter Humphries; Matthew Campbell

doi:10.1126/scitranslmed.3007616

Research ArticleRetinal Disease

IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

Sarah L. Doyle¹,²,*,
Ema Ozaki³,
Kiva Brennan⁴,
Marian M. Humphries³,
Kelly Mulfaul¹,²,
James Keaney³,
Paul F. Kenna³,⁵,
Arvydas Maminishkis⁶,
Anna-Sophia Kiang³,
Sean P. Saunders⁷,
Emily Hams⁷,
Ed C. Lavelle⁴,
Clair Gardiner⁴,
Padraic G. Fallon⁷,
Peter Adamson⁸,
Peter Humphries³ and
Matthew Campbell³,*

¹Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
²National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.
³Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.
⁴School of Biochemistry and Immunology, Immunology Research Centre, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.
⁵Research Foundation, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin 2, Ireland.
⁶National Eye Institute, National Institutes of Health, Bethesda, MD 20892–0001, USA.
⁷Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
⁸Ophthiris Discovery Performance Unit, GlaxoSmithKline, Stevenage SG1 2NY, UK.

↵*Corresponding author. E-mail: matthew.campbell{at}tcd.ie (M.C.); sarah.doyle{at}tcd.ie (S.L.D.)

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Science Translational Medicine 02 Apr 2014:
Vol. 6, Issue 230, pp. 230ra44
DOI: 10.1126/scitranslmed.3007616

Sarah L. Doyle

1Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

2National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

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For correspondence: matthew.campbell@tcd.ie sarah.doyle@tcd.ie

Ema Ozaki

3Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

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Kiva Brennan

4School of Biochemistry and Immunology, Immunology Research Centre, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.

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Marian M. Humphries

3Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

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Kelly Mulfaul

1Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

2National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

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James Keaney

3Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

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Paul F. Kenna

3Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

5Research Foundation, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin 2, Ireland.

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Arvydas Maminishkis

6National Eye Institute, National Institutes of Health, Bethesda, MD 20892–0001, USA.

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Anna-Sophia Kiang

3Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

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Sean P. Saunders

7Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

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Emily Hams

7Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

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Ed C. Lavelle

4School of Biochemistry and Immunology, Immunology Research Centre, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.

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Clair Gardiner

4School of Biochemistry and Immunology, Immunology Research Centre, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.

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Padraic G. Fallon

7Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

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Peter Adamson

8Ophthiris Discovery Performance Unit, GlaxoSmithKline, Stevenage SG1 2NY, UK.

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Peter Humphries

3Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

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Matthew Campbell

3Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

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For correspondence: matthew.campbell@tcd.ie sarah.doyle@tcd.ie

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IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

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