Contents
Vol 6, Issue 230
Contents
Focus
- Exon-Skipping Therapy: A Roadblock, Detour, or Bump in the Road?
Exon skipping is a promising therapeutic for Duchenne muscular dystrophy patients, but the road to drug approvals is foggy and may require more early-stage de-risking and regulatory guidance.
Research Articles
- IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration
IL-18 prevents choroidal neovascularization, the hallmark pathology of wet AMD, and is not toxic to the retinal pigment epithelium.
- Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody
CTLA-4 blocking antibody induces secondary hypophysitis by binding to CTLA-4 antigen and initiating a type II hypersensitivity reaction.
- Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue
Visualizing and quantifying the spatial relationships between T and B cells identifies adaptive immune cell networks in human inflammation.
Editors' Choice
- Micro(RNA)managing Endothelial Regeneration
Systemic targeting of miR-126 production might be useful in treating atherosclerosis.
- An Emerging Lung Cancer Biomarker
Molecular profiling of an exceptional response to the multitargeted kinase inhibitor sorafenib may have identified a new druggable oncogene in lung cancer.
- Dancing with the Scars: Choreography of the Macrophage Two Step After Myocardial Infarction
A nuclear receptor coordinates monocytes and macrophage subsets and functions after myocardial infarction to maximize healing.
- Unveiling Neutrophil—T Cell Interactions in HIV Infection
Human HIV infection causes T cell hyporesponsiveness by enhancing PD-L1 expression on neutrophils, promoting its binding to T cell PD-1.
- Something to Smile About in Stroke?
Facial nerve stimulation reduces the impact of ischemic stroke in a large animal model.
