Contents

Contents

• Focus

  • Exon-Skipping Therapy: A Roadblock, Detour, or Bump in the Road?

    By Eric P. Hoffman, Elizabeth M. McNally

    Science Translational Medicine02 Apr 2014 : 230fs14 Full AccessRestricted Access

    Exon skipping is a promising therapeutic for Duchenne muscular dystrophy patients, but the road to drug approvals is foggy and may require more early-stage de-risking and regulatory guidance.

    • Abstract
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• Research Articles

  • IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

    By Sarah L. Doyle, Ema Ozaki, Kiva Brennan, Marian M. Humphries, Kelly Mulfaul, James Keaney, Paul F. Kenna, Arvydas Maminishkis, Anna-Sophia Kiang, Sean P. Saunders, Emily Hams, Ed C. Lavelle, Clair Gardiner, Padraic G. Fallon, Peter Adamson, Peter Humphries, Matthew Campbell

    Science Translational Medicine02 Apr 2014 : 230ra44 Full AccessRestricted Access

    IL-18 prevents choroidal neovascularization, the hallmark pathology of wet AMD, and is not toxic to the retinal pigment epithelium.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody

    By Shintaro Iwama, Alessandra De Remigis, Margaret K. Callahan, Susan F. Slovin, Jedd D. Wolchok, Patrizio Caturegli

    Science Translational Medicine02 Apr 2014 : 230ra45 Full AccessRestricted Access

    CTLA-4 blocking antibody induces secondary hypophysitis by binding to CTLA-4 antigen and initiating a type II hypersensitivity reaction.

    • Editor's Summary
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    • Supplementary Materials

  • Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

    By Vladimir M. Liarski, Natalya Kaverina, Anthony Chang, Daniel Brandt, Denisse Yanez, Lauren Talasnik, Gianluca Carlesso, Ronald Herbst, Tammy O. Utset, Christine Labno, Yahui Peng, Yulei Jiang, Maryellen L. Giger, Marcus R. Clark

    Science Translational Medicine02 Apr 2014 : 230ra46 Full AccessRestricted Access

    Visualizing and quantifying the spatial relationships between T and B cells identifies adaptive immune cell networks in human inflammation.

    • Editor's Summary
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    • Supplementary Materials

• Editors' Choice

  • Micro(RNA)managing Endothelial Regeneration

    By Ebru Erbay

    Science Translational Medicine02 Apr 2014 : 230ec57 Full AccessRestricted Access

    Systemic targeting of miR-126 production might be useful in treating atherosclerosis.

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  • An Emerging Lung Cancer Biomarker

    By David E. Gerber

    Science Translational Medicine02 Apr 2014 : 230ec58 Full AccessRestricted Access

    Molecular profiling of an exceptional response to the multitargeted kinase inhibitor sorafenib may have identified a new druggable oncogene in lung cancer.

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  • Dancing with the Scars: Choreography of the Macrophage Two Step After Myocardial Infarction

    By Elvin Price

    Science Translational Medicine02 Apr 2014 : 230ec59 Full AccessRestricted Access

    A nuclear receptor coordinates monocytes and macrophage subsets and functions after myocardial infarction to maximize healing.

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  • Unveiling Neutrophil—T Cell Interactions in HIV Infection

    By Henrique Serezani

    Science Translational Medicine02 Apr 2014 : 230ec60 Full AccessRestricted Access

    Human HIV infection causes T cell hyporesponsiveness by enhancing PD-L1 expression on neutrophils, promoting its binding to T cell PD-1.

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  • Something to Smile About in Stroke?

    By Nathan White

    Science Translational Medicine02 Apr 2014 : 230ec61 Full AccessRestricted Access

    Facial nerve stimulation reduces the impact of ischemic stroke in a large animal model.

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