Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17–Driven Inflammatory Bone Loss

Niki M. Moutsopoulos; Joanne Konkel; Mojgan Sarmadi; Mehmet A. Eskan; Teresa Wild; Nicolas Dutzan; Loreto Abusleme; Camille Zenobia; Kavita B. Hosur; Toshiharu Abe; Gulbu Uzel; WanJun Chen; Triantafyllos Chavakis; Steven M. Holland; George Hajishengallis

doi:10.1126/scitranslmed.3007696

Research ArticlePERIODONTITIS

Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17–Driven Inflammatory Bone Loss

Niki M. Moutsopoulos¹,*,
Joanne Konkel²,
Mojgan Sarmadi¹,
Mehmet A. Eskan³,
Teresa Wild¹,
Nicolas Dutzan¹,
Loreto Abusleme¹,
Camille Zenobia⁴,
Kavita B. Hosur⁴,
Toshiharu Abe⁴,
Gulbu Uzel⁵,
WanJun Chen²,
Triantafyllos Chavakis⁶,
Steven M. Holland⁵ and
George Hajishengallis⁴,*

¹National Institute of Dental and Craniofacial Research, Oral Immunity and Infection Unit, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.
²National Institute of Dental and Craniofacial Research, Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.
³Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
⁴Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.
⁵National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
⁶Department of Medicine, Department of Clinical Pathobiochemistry, and Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

↵*Corresponding author: E-mail: nmoutsop{at}mail.nih.gov (N.M.); geoh{at}upenn.edu (G.H.)

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Science Translational Medicine 26 Mar 2014:
Vol. 6, Issue 229, pp. 229ra40
DOI: 10.1126/scitranslmed.3007696

Niki M. Moutsopoulos

1National Institute of Dental and Craniofacial Research, Oral Immunity and Infection Unit, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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For correspondence: nmoutsop@mail.nih.gov geoh@upenn.edu

Joanne Konkel

2National Institute of Dental and Craniofacial Research, Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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Mojgan Sarmadi

1National Institute of Dental and Craniofacial Research, Oral Immunity and Infection Unit, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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Mehmet A. Eskan

3Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, Louisville, KY 40202, USA.

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Teresa Wild

1National Institute of Dental and Craniofacial Research, Oral Immunity and Infection Unit, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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Nicolas Dutzan

1National Institute of Dental and Craniofacial Research, Oral Immunity and Infection Unit, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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Loreto Abusleme

1National Institute of Dental and Craniofacial Research, Oral Immunity and Infection Unit, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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Camille Zenobia

4Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

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Kavita B. Hosur

4Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

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Toshiharu Abe

4Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

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Gulbu Uzel

5National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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WanJun Chen

2National Institute of Dental and Craniofacial Research, Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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Triantafyllos Chavakis

6Department of Medicine, Department of Clinical Pathobiochemistry, and Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

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Steven M. Holland

5National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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George Hajishengallis

4Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

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For correspondence: nmoutsop@mail.nih.gov geoh@upenn.edu

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Inflammatory bone loss from periodontal infections in leukocyte adhesion deficiency disease can be reversed by treatment with antibodies to IL-17 or IL-23.

Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17–Driven Inflammatory Bone Loss

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