LetterDrug Discovery

Comment on “Drug Discovery: Turning the Titanic”

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Science Translational Medicine  26 Mar 2014:
Vol. 6, Issue 229, pp. 229le2
DOI: 10.1126/scitranslmed.3008763

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The pathobiology-based approach to research and development has been the dominant paradigm for successful drug discovery over the last decades. We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.

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