Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients

Bernhard Mlecnik; Gabriela Bindea; Helen K. Angell; Maria Stella Sasso; Anna C. Obenauf; Tessa Fredriksen; Lucie Lafontaine; Amelie M. Bilocq; Amos Kirilovsky; Marie Tosolini; Maximilian Waldner; Anne Berger; Wolf Herman Fridman; Arash Rafii; Viia Valge-Archer; Franck Pagès; Michael R. Speicher; Jérôme Galon

doi:10.1126/scitranslmed.3007240

Research ArticleCancer

Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients

Bernhard Mlecnik¹,²,³,*,
Gabriela Bindea¹,²,³,*,
Helen K. Angell¹,²,³,
Maria Stella Sasso¹,²,³,
Anna C. Obenauf⁴,
Tessa Fredriksen¹,²,³,
Lucie Lafontaine¹,²,³,
Amelie M. Bilocq¹,²,³,
Amos Kirilovsky¹,²,³,
Marie Tosolini¹,²,³,
Maximilian Waldner¹,²,³,⁵,
Anne Berger⁶,
Wolf Herman Fridman²,³,⁷,
Arash Rafii⁸,
Viia Valge-Archer⁹,
Franck Pagès¹,²,³,¹⁰,
Michael R. Speicher⁴ and
Jérôme Galon¹,²,³,†

¹INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.
²Université Paris Descartes, Paris F-75006, France.
³Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.
⁴Institute of Human Genetics, Medical University of Graz, Graz A-8036, Austria.
⁵University of Erlangen-Nuremberg, Erlangen G-91054, Germany.
⁶Assistance Publique-Hopitaux de Paris, Department of General and Digestive Surgery, Paris F-75015, France.
⁷INSERM UMRS1138, Team 13, Paris F-75006, France.
⁸Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha Q-10065, Qatar.
⁹MedImmune, Cambridge CG21 6GH, UK.
¹⁰Department of Immunology, Georges Pompidou European Hospital, Paris F-75015, France.

↵†Corresponding author. E-mail: jerome.galon{at}crc.jussieu.fr

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Translational Medicine 19 Mar 2014:
Vol. 6, Issue 228, pp. 228ra37
DOI: 10.1126/scitranslmed.3007240

Bernhard Mlecnik

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gabriela Bindea

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Helen K. Angell

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Maria Stella Sasso

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anna C. Obenauf

4Institute of Human Genetics, Medical University of Graz, Graz A-8036, Austria.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tessa Fredriksen

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lucie Lafontaine

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Amelie M. Bilocq

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Amos Kirilovsky

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Marie Tosolini

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Maximilian Waldner

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

5University of Erlangen-Nuremberg, Erlangen G-91054, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anne Berger

6Assistance Publique-Hopitaux de Paris, Department of General and Digestive Surgery, Paris F-75015, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wolf Herman Fridman

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

7INSERM UMRS1138, Team 13, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Arash Rafii

8Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha Q-10065, Qatar.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Viia Valge-Archer

9MedImmune, Cambridge CG21 6GH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Franck Pagès

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

10Department of Immunology, Georges Pompidou European Hospital, Paris F-75015, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael R. Speicher

4Institute of Human Genetics, Medical University of Graz, Graz A-8036, Austria.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jérôme Galon

1INSERM UMRS1138, Laboratory of Integrative Cancer Immunology, Paris F-75006, France.

2Université Paris Descartes, Paris F-75006, France.

3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris F-75006, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: jerome.galon@crc.jussieu.fr

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools