Contents
Vol 6, Issue 228
Contents
Editorial
- TRANSLOCATION Project: How to Get Good Drugs into Bad Bugs
The TRANSLOCATION project aims to decipher how to help antibiotics penetrate Gram-negative bacteria’s double-envelope defense.
Focus
- The A4 Study: Stopping AD Before Symptoms Begin?
A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer’s disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.
Research Articles
- Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients
Genomic alterations result in changes of immune cell densities within the tumor.
- Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines
RV144 vaccination induced polyfunctional antibody Fc-effector responses, whereas VAX003 vaccination increased inhibitory IgG4 antibodies.
- Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination
A V1-V2 IgG3 response to HIV correlates with a decreased risk of HIV-1 infection and is one vaccine-induced humoral response that is higher in a clinical trial showing HIV-1 vaccine efficacy compared to a trial showing nonefficacy.
Editors' Choice
- Genetic Basis for Variations in the Effect of Physical Activity on Cardiometabolic Risk
Negative effects of PPARA H-23 haplotype on individual cardiometabolic risk are attenuated by physical activity.
- High Steaks for Cancer and Aging
A new study reveals that protein intake influences cancer risk, diabetes, and mortality during aging.
- Knocking Out HIV Infection?
Infusion of HIV-infected patients’ own immune cells after genetic alteration was safe and made the cells more resistant to HIV infection.
- The Last Line of Defense Against Atherosclerosis
The miRNA miR-126 protects against atherosclerosis by promoting a healthy endothelium.
Letter
- Author Response to Comment on “Power of Rare Diseases: Found in Translation”
The study of rare diseases in both academic and industry settings yields new knowledge about human pathophysiology and ultimately helps patients.