19 March 2014
Vol 6, Issue 228

About The Cover

Cover image expansion

ONLINE COVER Eliminate the Negative. The need for new antimicrobials is especially urgent for infections caused by Gram-negative bacteria, which have barriers that block penetration by drugs. Shown is the Gram-negative bacterium Acinetobacter baumannii, a short, rod-shaped (coccobacillus) opportunistic pathogen that infects people with compromised immune systems and is a recently recognized player in hospital-derived (nosocomial) infections. In this issue, Stavenger and Winterhalter describe the TRANSLOCATION project, a part of the Innovative Medicines Initiative's "New Drugs 4 Bad Bugs" venture that aims to find ways to help antibiotics breach Gram-negative bacteria's double-envelope defense. [CREDIT: DENNIS KUNKEL MICROSCOPY]