Contents

Contents

• Editorial

  • TRANSLOCATION Project: How to Get Good Drugs into Bad Bugs

    By Robert A. Stavenger, Mathias Winterhalter

    Science Translational Medicine19 Mar 2014 : 228ed7 Full AccessRestricted Access

    The TRANSLOCATION project aims to decipher how to help antibiotics penetrate Gram-negative bacteria’s double-envelope defense.

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• Focus

  • The A4 Study: Stopping AD Before Symptoms Begin?

    By Reisa A. Sperling, Dorene M. Rentz, Keith A. Johnson, Jason Karlawish, Michael Donohue, David P. Salmon, Paul Aisen

    Science Translational Medicine19 Mar 2014 : 228fs13 Full AccessRestricted Access

    A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer’s disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.

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• Research Articles

  • Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients

    By Bernhard Mlecnik, Gabriela Bindea, Helen K. Angell, Maria Stella Sasso, Anna C. Obenauf, Tessa Fredriksen, Lucie Lafontaine, Amelie M. Bilocq, Amos Kirilovsky, Marie Tosolini, Maximilian Waldner, Anne Berger, Wolf Herman Fridman, Arash Rafii, Viia Valge-Archer, Franck Pagès, Michael R. Speicher, Jérôme Galon

    Science Translational Medicine19 Mar 2014 : 228ra37 Full AccessRestricted Access

    Genomic alterations result in changes of immune cell densities within the tumor.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

    By Amy W. Chung, Musie Ghebremichael, Hannah Robinson, Eric Brown, Ickwon Choi, Sophie Lane, Anne-Sophie Dugast, Matthew K. Schoen, Morgane Rolland, Todd J. Suscovich, Alison E. Mahan, Larry Liao, Hendrik Streeck, Charla Andrews, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Mark S. de Souza, Jaranit Kaewkungwal, Punnee Pitisuttithum, Donald Francis, Nelson L. Michael, Jerome H. Kim, Chris Bailey-Kellogg, Margaret E. Ackerman, Galit Alter

    Science Translational Medicine19 Mar 2014 : 228ra38 Full AccessRestricted Access

    RV144 vaccination induced polyfunctional antibody Fc-effector responses, whereas VAX003 vaccination increased inhibitory IgG4 antibodies.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

    By Nicole L. Yates, Hua-Xin Liao, Youyi Fong, Allan deCamp, Nathan A. Vandergrift, William T. Williams, S. Munir Alam, Guido Ferrari, Zhi-yong Yang, Kelly E. Seaton, Phillip W. Berman, Michael D. Alpert, David T. Evans, Robert J. O’Connell, Donald Francis, Faruk Sinangil, Carter Lee, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Abraham Pinter, Susan Zolla-Pazner, Peter B. Gilbert, Gary J. Nabel, Nelson L. Michael, Jerome H. Kim, David C. Montefiori, Barton F. Haynes, Georgia D. Tomaras

    Science Translational Medicine19 Mar 2014 : 228ra39 Full AccessRestricted Access

    A V1-V2 IgG3 response to HIV correlates with a decreased risk of HIV-1 infection and is one vaccine-induced humoral response that is higher in a clinical trial showing HIV-1 vaccine efficacy compared to a trial showing nonefficacy.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

• Editors' Choice

  • Genetic Basis for Variations in the Effect of Physical Activity on Cardiometabolic Risk

    By Egle Bytautiene

    Science Translational Medicine19 Mar 2014 : 228ec48 Full AccessRestricted Access

    Negative effects of PPARA H-23 haplotype on individual cardiometabolic risk are attenuated by physical activity.

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  • High Steaks for Cancer and Aging

    By Christopher Gregg

    Science Translational Medicine19 Mar 2014 : 228ec49 Full AccessRestricted Access

    A new study reveals that protein intake influences cancer risk, diabetes, and mortality during aging.

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  • Knocking Out HIV Infection?

    By Anandi N. Sheth

    Science Translational Medicine19 Mar 2014 : 228ec50 Full AccessRestricted Access

    Infusion of HIV-infected patients’ own immune cells after genetic alteration was safe and made the cells more resistant to HIV infection.

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  • The Last Line of Defense Against Atherosclerosis

    By Deepak Voora

    Science Translational Medicine19 Mar 2014 : 228ec51 Full AccessRestricted Access

    The miRNA miR-126 protects against atherosclerosis by promoting a healthy endothelium.

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• Letter

  • Author Response to Comment on “Power of Rare Diseases: Found in Translation”

    By Mark C. Fishman

    Science Translational Medicine19 Mar 2014 : 228lr1 Full AccessRestricted Access

    The study of rare diseases in both academic and industry settings yields new knowledge about human pathophysiology and ultimately helps patients.

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