Contents
Vol 6, Issue 227
Contents
Focus
- Meeting the Demand for Pediatric Clinical Trials
The bid for high-quality, cost-effective pediatric clinical trials requires robust research and regulatory playgrounds and an appropriately trained workforce.
- Maladapted Endothelial Cells Flip the Mesenchymal Switch
Endothelial cells in the neointima undergo a transition to the mesenchymal phenotype, suggesting a therapeutic target for vein graft restenosis (Cooley et al., this issue).
Research Articles
- Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity
Wiskott-Aldrich syndrome gene therapy is feasible, but γ-retroviral vectors contribute a substantial risk of leukemogenesis.
- TGF-β Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling
In vivo endothelial cell fate mapping demonstrates that TGF-β signaling is a central pathway regulating the endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling.
- Postexposure Protection of Macaques from Vaginal SHIV Infection by Topical Integrase Inhibitors
Postexposure protection of macaques from SHIV infection by a gel containing integrase inhibitors.
- Intestinal Inhibition of the Na+/H+ Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na+ Uptake in Humans
An inhibitor of intestinal NHE3 reduces absorption of dietary sodium in rats and humans and prevents salt-induced cardiorenal injury in nephrectomized rats.
Editors' Choice
- The Serpin Shield
Serpins help breast and lung cancer cells metastasize to the brain by annulling stromal defenses and co-opting capillaries.
- Sifting for Diagnostic Gold
Nanoporous silica thin films can enrich for low-abundance serum peptides in clinical samples.
- Got Milk Antibodies?
Secreted immunoglobulins in breast milk may promote long-term benefits against intestinal inflammatory diseases.
- Are Two Heads Really Better than One?
The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.
- New Biology Identified by Genetic Analysis of Nonalcoholic Fatty Liver Disease
Genetic variation in TM6SF2 predisposes to nonalcoholic fatty liver disease, potentially through impairment of VLDL secretion.
