Research ArticleAlzheimer’s Disease

Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease

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Science Translational Medicine  05 Mar 2014:
Vol. 6, Issue 226, pp. 226ra30
DOI: 10.1126/scitranslmed.3007901

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  • Increased brain tau sequestration and its longitudinal reduction in CSF in advanced AD
    • Nunzio Pomara, Director, Geriatric Psychiatry Division
    • Other Contributors:

    Fagan and colleagues (1) recently reported a surprising finding from a longitudinal study in carriers and non carriers of autosomal-dominant Alzheimer's disease (ADAD) mutations. They showed that in mutation carriers, the concentrations of a number of CSF markers of neuronal death/injury including tau, ptau181 (phosphorylated tau) and VILIP-1 (visin-like protein-1), increased in those in the asymptomatic phase, 10 to...

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    Competing Interests: None declared.