05 March 2014
Vol 6, Issue 226
  • Contents

    • Editorial

      • Neglected Diseases, Delinquent Diagnostics

        Modest investments in diagnostic technologies for neglected diseases can drive dramatic health-outcome improvements in resource-poor settings.

    • Focus

      • Angiophagy: Clearing or Clogging Microvessels?

        The body clears small clots from blood vessels through a process called angiophagy, opening up new approaches to combat cerebral and cardiac microvascular occlusive diseases (Grutzendler et al., this issue).

    • Research Articles

    • Editors' Choice

      • Insulin: Food for Thought

        Intranasal insulin improves cognitive function in individuals with type 2 diabetes.

      • To Catch a Pre-Leukemia

        DNMT3A mutations occur in pre-leukemic hematopoietic stem cells and define early-stage events in the progression to acute myeloid leukemia.

      • Taking the Fight Outside

        Engineered miniature wells connected to biomimetic paths attract cancer cells away from the tumor site for eradication.

      • SORT ing Out That Pesky Cholesterol

        SORT1 interacts with PCSK9 to facilitate its secretion from the liver, which regulates levels of plasma low-density lipoprotein cholesterol.

About The Cover

Cover image expansion

ONLINE COVER Clearing Out Clots. The formation of clots, or emboli, in small blood vessels is common, and the body responds by forcing them out by hemodynamic pressure or dissolving them by the fibrinolytic system. In this issue, Grutzendler et al. identify another clot-clearing mechanism called "angiophagy," where endothelial cells engulf the clot and pull it out of the vasculature, into the perivascular space. Although angiophagy initially blocks blood flow while encompassing the emboli, it ultimately removes clots and restores flow to organs such as the lung, kidney, brain, heart, and retina—the latter of which was demonstrated in humans. See related Focus by Iadecola. [CREDIT: V. ALTOUNIAN/SCIENCE TRANSLATIONAL MEDICINE]