Contents
Vol 6, Issue 226
Contents
Editorial
- Neglected Diseases, Delinquent Diagnostics
Modest investments in diagnostic technologies for neglected diseases can drive dramatic health-outcome improvements in resource-poor settings.
Focus
- Angiophagy: Clearing or Clogging Microvessels?
The body clears small clots from blood vessels through a process called angiophagy, opening up new approaches to combat cerebral and cardiac microvascular occlusive diseases (Grutzendler et al., this issue).
Research Articles
- Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease
Longitudinal cerebrospinal fluid biomarker analyses reveal decreases in neuronal injury markers in later stages of autosomal-dominant Alzheimer’s disease.
- Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation
Endothelial engulfment of emboli (angiophagy) occurs in microvascular beds throughout the body, resulting in emboli extravasation and vessel recanalization.
- Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy
Intratumoral treatment with an oncolytic virus results in inflammatory infiltrates in distant tumors and sensitizes the tumors to immune-mediated rejection in the setting of immunotherapy with CTLA-4 blocking antibodies.
Editors' Choice
- Insulin: Food for Thought
Intranasal insulin improves cognitive function in individuals with type 2 diabetes.
- To Catch a Pre-Leukemia
DNMT3A mutations occur in pre-leukemic hematopoietic stem cells and define early-stage events in the progression to acute myeloid leukemia.
- Taking the Fight Outside
Engineered miniature wells connected to biomimetic paths attract cancer cells away from the tumor site for eradication.
- SORT ing Out That Pesky Cholesterol
SORT1 interacts with PCSK9 to facilitate its secretion from the liver, which regulates levels of plasma low-density lipoprotein cholesterol.
