ReportsPsoriasis

Targeting miR-21 to Treat Psoriasis

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Science Translational Medicine  26 Feb 2014:
Vol. 6, Issue 225, pp. 225re1
DOI: 10.1126/scitranslmed.3008089

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A miR-21 Target in Psoriasis

Psoriasis is a common inflammatory skin disease with no cure to date. Several targeted therapies are being tested in different clinical trials. Previous reports have shown that the microRNA miR-21 is expressed in psoriasis tissue, but whether miR-21 is causally involved in the disease is unclear. In new work, Guinea-Viniegra and colleagues target miR-21 using LNA-modified anti–miR-21 compounds. The authors show that antagonizing miR-21 in a psoriasis-like mouse model and in a mouse xenotransplantation model using patient-derived psoriasis tissue reduced psoriasis pathology. Thus, miR-21 may be a useful target in the treatment of psoriasis.

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