Research ArticleCancer

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

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Science Translational Medicine  19 Feb 2014:
Vol. 6, Issue 224, pp. 224ra24
DOI: 10.1126/scitranslmed.3007094

Article Information

vol. 6 no. 224 224ra24

PubMed: 
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History: 
  • Received for publication July 19, 2013
  • Accepted for publication January 14, 2014

Author Information

  1. Chetan Bettegowda1,2,*,
  2. Mark Sausen1,*,,
  3. Rebecca J. Leary1,*,,
  4. Isaac Kinde1,*,
  5. Yuxuan Wang1,
  6. Nishant Agrawal1,2,
  7. Bjarne R. Bartlett1,3,
  8. Hao Wang1,
  9. Brandon Luber1,
  10. Rhoda M. Alani4,
  11. Emmanuel S. Antonarakis1,
  12. Nilofer S. Azad1,
  13. Alberto Bardelli5,6,7,
  14. Henry Brem2,
  15. John L. Cameron2,
  16. Clarence C. Lee8,
  17. Leslie A. Fecher9,10,
  18. Gary L. Gallia2,
  19. Peter Gibbs11,12,
  20. Dung Le1,3,
  21. Robert L. Giuntoli2,
  22. Michael Goggins2,
  23. Michael D. Hogarty13,
  24. Matthias Holdhoff1,
  25. Seung-Mo Hong2,14,
  26. Yuchen Jiao1,
  27. Hartmut H. Juhl15,
  28. Jenny J. Kim1,
  29. Giulia Siravegna16,
  30. Daniel A. Laheru1,
  31. Calogero Lauricella16,
  32. Michael Lim2,
  33. Evan J. Lipson1,
  34. Suely Kazue Nagahashi Marie17,
  35. George J. Netto2,
  36. Kelly S. Oliner18,
  37. Alessandro Olivi2,
  38. Louise Olsson19,
  39. Gregory J. Riggins2,
  40. Andrea Sartore-Bianchi16,
  41. Kerstin Schmidt1,
  42. le-Ming Shih2,
  43. Sueli Mieko Oba-Shinjo17,
  44. Salvatore Siena16,
  45. Dan Theodorescu20,
  46. Jeanne Tie11,
  47. Timothy T. Harkins8,
  48. Silvio Veronese16,
  49. Tian-Li Wang2,
  50. Jon D. Weingart2,
  51. Christopher L. Wolfgang2,
  52. Laura D. Wood2,
  53. Dongmei Xing2,
  54. Ralph H. Hruban2,
  55. Jian Wu1,21,§,
  56. Peter J. Allen22,
  57. C. Max Schmidt23,
  58. Michael A. Choti2,,
  59. Victor E. Velculescu1,||,
  60. Kenneth W. Kinzler1,||,
  61. Bert Vogelstein1,||,
  62. Nickolas Papadopoulos1,|| and
  63. Luis A. Diaz Jr1,3,||
  1. 1Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.
  2. 2Departments of Surgery, Medicine, Pathology, Obstetrics and Gynecology, Otolaryngology, and Neurosurgery at Johns Hopkins, Baltimore, MD 21231, USA.
  3. 3Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21231, USA.
  4. 4Department of Dermatology, Boston University, Boston, MA 02215, USA.
  5. 5Institute for Cancer Research and Treatment at Candiolo, University of Torino, Candiolo, Turin 10060, Italy.
  6. 6Department of Oncology, University of Torino, Candiolo, Turin 10060, Italy.
  7. 7FIRC Institute of Molecular Oncology (IFOM), Milan 20139, Italy.
  8. 8Advanced Applications and Collaborations, Life Technologies, Foster City, CA 94404, USA.
  9. 9Division of Oncology, University of Indiana, Indianapolis, IN 46202, USA.
  10. 10Indiana University Health, Indianapolis, IN 46202, USA.
  11. 11Ludwig Institute for Cancer Research, Melbourne Branch, Royal Melbourne Hospital, Melbourne, Victoria 3084, Australia.
  12. 12Western Hospital, Melbourne, Victoria 3011, Australia.
  13. 13Division of Oncology, The Children’s Hospital of Philadelphia and the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  14. 14Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
  15. 15Indivumed GmbH, Hamburg 20251, Germany.
  16. 16Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda, Milan 20162, Italy.
  17. 17Department of Neurology and Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  18. 18Amgen Inc., Thousand Oaks, CA 91320, USA.
  19. 19Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm SE-171 76, Sweden.
  20. 20University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA.
  21. 21MyGenostics Inc., 801 West Baltimore Street, Baltimore, MD 21205, USA.
  22. 22Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  23. 23Departments of Surgery, Biochemistry, and Molecular Biology, Indiana University, Indianapolis, IN 46202, USA.
  1. ||Corresponding authors. E-mail: ldiaz1{at}jhmi.edu (L.A.D.); npapado1{at}jhmi.edu (N.P.); vogelbe{at}jhmi.edu (B.V.); kinzlke{at}jhmi.edu (K.W.K.); velculescu{at}jhmi.edu (V.E.V.)
  • * These authors contributed equally to this work.

  • Present address: Personal Genome Diagnostics, Baltimore, MD 21224, USA.

  • Present address: Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

  • § Present address: State Key Laboratory of Cancer Biology, Cell Engineering Research Center and Department of Cell Biology, The Fourth Military Medical University, Xi’an 710032, P. R. China.

  • Present address: Department of Surgery University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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