Contents
Vol 6, Issue 224
Contents
Editorial
- UK Biobank Data: Come and Get It
UK Biobank invites scientists to make use of the vast (and growing) amounts of data in this open-access resource for public health research.
Commentary
- Making Prospective Registration of Observational Research a Reality
Key information about human observational studies should be publicly available before the study is initiated.
Research Articles
- Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Circulating tumor DNA can be used in a variety of clinical and investigational settings across tumor types and stages for screening, diagnosis, and identifying mutations responsible for therapeutic response and drug resistance.
- Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
CD19 CAR T cell therapy induces complete remissions in 88% of 16 adult patients with relapsed or refractory acute lymphoblastic leukemia.
- Blockade of EGFR and MEK Intercepts Heterogeneous Mechanisms of Acquired Resistance to Anti-EGFR Therapies in Colorectal Cancer
Colorectal cancers that become resistant to EGFR inhibitors through a variety of mechanisms can be effectively treated by inhibiting MEK in conjunction with EGFR.
- Cyclin A2 Induces Cardiac Regeneration After Myocardial Infarction Through Cytokinesis of Adult Cardiomyocytes
Cyclin A2 mediates cardiac regeneration of infarcted porcine hearts.
Editors' Choice
- Seeking Harmony Among Cancer Killers
A rationally devised duet of apoptotic drugs and immune adjuvants boosts antitumor activity.
- Boosting Metabolism by Sweetening the Gut
Dietary fiber provides metabolic benefits, including body weight and glucose control, through microbiota-induced intestinal glucose production.
- A Fine Line Between Healing and Fibrosis
The liver’s microvascular endothelium lies at the crux of regeneration and fibrosis.
- Too Much of a Good Channel in Pulmonary Arterial Hypertension
An increase in the expression of the chloride intracellular channel 4 mediates endothelial dysfunction and vascular remodeling in pulmonary arterial hypertension.
