CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

Mehdi Rashighi; Priti Agarwal; Jillian M. Richmond; Tajie H. Harris; Karen Dresser; Ming-Wan Su; Youwen Zhou; April Deng; Christopher A. Hunter; Andrew D. Luster; John E. Harris

doi:10.1126/scitranslmed.3007811

Research ArticleVitiligo

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

Mehdi Rashighi¹,
Priti Agarwal¹,
Jillian M. Richmond¹,
Tajie H. Harris²,*,
Karen Dresser³,
Ming-Wan Su⁴,
Youwen Zhou⁴,
April Deng³,
Christopher A. Hunter²,
Andrew D. Luster⁵ and
John E. Harris¹,†

¹Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
²Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
³Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
⁴Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia V5Z 4E8, Canada.
⁵Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

↵†Corresponding author. E-mail: john.harris{at}umassmed.edu

↵* Present address: Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

See allHide authors and affiliations

Science Translational Medicine 12 Feb 2014:
Vol. 6, Issue 223, pp. 223ra23
DOI: 10.1126/scitranslmed.3007811

Mehdi Rashighi

1Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Priti Agarwal

1Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jillian M. Richmond

1Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tajie H. Harris

2Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Karen Dresser

3Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ming-Wan Su

4Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia V5Z 4E8, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Youwen Zhou

4Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia V5Z 4E8, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

April Deng

3Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christopher A. Hunter

2Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andrew D. Luster

5Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

John E. Harris

1Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: john.harris@umassmed.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

Log in to view full text

via AAAS login

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Become an AAAS Member
Activate your Account
Purchase Access to Other Journals in the Science Family
Account Help

As a service to the community, this article is available for free. Existing users log in.

Become a AAAS member
Account help

Log in through your institution

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

Log in to view full text

Log in through your institution

Log in through your institution

More options

Science Translational Medicine

Article Tools