12 February 2014
Vol 6, Issue 223

About The Cover

Cover image expansion

ONLINE COVER Scratching the Itch of Autoimmunity. Psoriasis is an immune-mediated skin disease characterized by scaly, reddened, itchy patches. There is no cure for psoriasis, although different treatments can control the symptoms. In this issue, Perera et al. use an integrative biology approach combining human disease transcriptome data sets with clinically relevant in vivo models to identify that the serine/threonine kinase PIM1 is a critical checkpoint for human skin inflammation and potential target in psoriasis. [CREDIT: COURTNEY KEATING/iSTOCKPHOTO.COM]