Contents
Vol 6, Issue 223
Contents
Editorial
- From Silos to Multilingual Science
Scientists who can communicate across disciplines are essential to fluid translation and must be developed systematically through targeted training.
Focus
- Sorting the Role of SORLA in Alzheimer’s Disease
Cell culture and mouse models unravel how the SORLA receptor negatively regulates β-amyloid (Caglayan et al.).
Research Articles
- Lysosomal Sorting of Amyloid-β by the SORLA Receptor Is Impaired by a Familial Alzheimer’s Disease Mutation
A familial AD mutation in SORL1 disrupts the ability of the sorting receptor SORLA to mediate intracellular degradation of Aβ peptides.
- Local Hydrogel Release of Recombinant TIMP-3 Attenuates Adverse Left Ventricular Remodeling After Experimental Myocardial Infarction
Delivery of a hydrogel providing sustained release of recombinant TIMP-3 attenuated adverse ventricular remodeling after myocardial infarction in pigs.
- Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis
The serine/threonine kinase PIM1 is a critical checkpoint for human skin inflammation and potential target in psoriasis.
- CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo
Neutralizing CXCL10 reverses established vitiligo.
Editors' Choice
- Golden Cage for Triggered Release
Reservoir capped with an externally tunable porous membrane enables light-triggered release of drugs.
- Neutrophils: Another Case of Wrongful Conviction?
Oxygen depletion by the neutrophil respiratory burst induces a protective stress response in mucosal epithelial cells.
- Cooking Tips for Pluripotency: Add Acid and Squeeze
Physical stress and low pH can reprogram somatic cells into a pluripotent embryonic stem cell–like state.
- Biting the FLIPR that Feeds
Immune cells are activated by long, filamentous flow-induced protrusions (FLIPRs) extending from platelets.
