Research ArticleCardiovascular Disease

A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk

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Science Translational Medicine  05 Feb 2014:
Vol. 6, Issue 222, pp. 222ra17
DOI: 10.1126/scitranslmed.3006804

Article Information

vol. 6 no. 222 222ra17

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 14, 2013
  • Accepted for publication December 31, 2013
  • .

Author Information

  1. Magnus Larsson1,2,*,
  2. Veronika Rayzman3,*,
  3. Marc W. Nolte4,*,
  4. Katrin F. Nickel1,5,6,*,
  5. Jenny Björkqvist1,5,
  6. Anne Jämsä1,5,
  7. Matthew P. Hardy3,
  8. Marion Fries4,
  9. Stefan Schmidbauer4,
  10. Patricia Hedenqvist7,
  11. Michael Broomé2,8,
  12. Ingo Pragst4,
  13. Gerhard Dickneite4,
  14. Michael J. Wilson3,
  15. Andrew D. Nash3,
  16. Con Panousis3,* and
  17. Thomas Renné1,5,6,*,
  1. 1Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, SE-171 76 Stockholm, Sweden.
  2. 2ECMO Department, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
  3. 3CSL Limited, Bio21 Institute, 30 Flemington Road, Parkville, Victoria 3010, Australia.
  4. 4CSL Behring GmbH, Emil-von-Behring-Straße 76, 35041 Marburg, Germany.
  5. 5Center of Molecular Medicine, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
  6. 6Institute of Clinical Chemistry, University Hospital Hamburg-Eppendorf, D-20246 Hamburg, Germany.
  7. 7Department of Clinical Sciences, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.
  8. 8Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
  1. Corresponding author. E-mail: thomas{at}renne.net
  • * These authors contributed equally to this work.

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