Contents
Vol 6, Issue 222
Contents
Focus
- Ascorbate Combination Therapy: New Tool in the Anticancer Toolbox?
The addition of high-dose ascorbate to existing anticancer treatment strategies can improve efficacy and decrease toxicity—but not in all patients or with all combination therapies.
- Extracorporeal Circulation Without Bleeding
A newly created antibody protects against blood coagulation in extracorporeal bypass systems without bleeding risk in vivo.
Research Articles
- Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun–Regulated Macrophage Activation
The molecular correlates of heterogeneous endometriosis symptoms support a role for innate inflammatory responses converging upon c-Jun and NFκB signaling cascades.
- A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk
Blocking the enzyme that initiates the intrinsic coagulation pathway protects against thrombosis in bypass systems and does not cause excess bleeding in vivo.
- High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy
Pharmacological use of ascorbate (vitamin C) enhanced chemosensitivity of ovarian cancer in preclinical models and reduced chemotherapy-associated toxicity in patients.
- Restoring Natural Sensory Feedback in Real-Time Bidirectional Hand Prostheses
A multigrasp, bidirectional hand prosthesis delivers dynamic sensory feedback, allowing a user with a hand amputation to achieve fine grasping force control and realistic object sensing.
Editors' Choice
- Diabetes, DNA Methylation, and in Utero Environment
Exposure to a diabetic in utero environment alters the methylation of genes associated with diabetes and Notch signaling in Pima Indian subjects.
- Schizophrenia at the Synapse
Proteins that power excitatory synapses are mutated in schizophrenia.
- How Much Do Drugs Matter?
Drugs penetrate poorly into the lymphatic tissues, which are sites of persistent HIV replication.
- PREDICTing the Era of Personalized Medicine
Most patients may benefit from preemptive pharmacogenetic testing.
