22 January 2014
Vol 6, Issue 220
  • Contents

    • Perspective

    • Research Articles

    • Editors' Choice

      • Giving Leptin a Second Chance

        GLP-1/glucagon co-agonist may help restore leptin responsiveness in diet-induced-obese mice that remain on a high-fat diet.

      • Friendly Bacteria

        Engineered bacterial membrane vesicles target cancer cells and deliver small interfering RNA to halt tumor growth.

      • A Metabolic Relic

        A risk haplotype common among Mexican and Latin American people implicates triacylglycerol metabolism in susceptibility to type 2 diabetes.

About The Cover

Cover image expansion

ONLINE COVER Restoring Muscle Strength. Shown is a cross-section of a quadriceps muscle from a dog with X-linked myotubular myopathy 1 month after infusion of an AAV8 vector carrying the MTM1 therapeutic gene. Single-dose gene therapy reversed muscle pathology, restored muscle strength, and improved survival in mouse and dog models of X-linked myotubular myopathy, a fatal pediatric disease that affects the entire musculature (Childers et al.) . [CREDIT: M. LAWLOR, H. MENG/ MEDICAL COLLEGE OF WISCONSIN]