22 January 2014
Vol 6, Issue 220

About The Cover

Cover image expansion

ONLINE COVER Restoring Muscle Strength. Shown is a cross-section of a quadriceps muscle from a dog with X-linked myotubular myopathy 1 month after infusion of an AAV8 vector carrying the MTM1 therapeutic gene. Single-dose gene therapy reversed muscle pathology, restored muscle strength, and improved survival in mouse and dog models of X-linked myotubular myopathy, a fatal pediatric disease that affects the entire musculature (Childers et al.) . [CREDIT: M. LAWLOR, H. MENG/ MEDICAL COLLEGE OF WISCONSIN]