Contents
Vol 6, Issue 219
Contents
Focus
- Multiplexed Protein Analysis
Multiplexed protein analysis using an antibody-DNA barcoding approach could accelerate early detection and monitoring of cancer biomarkers in patient samples, as well as unravel pathways leading to therapeutic response or resistance (Ullal et al., this issue).
- MARCOing Monocytes for Elimination
Eliminating inflammatory monocytes using microparticles that bind to the MARCO receptor represents a promising strategy to reduce inflammation and injury (Getts et al., this issue).
Research Articles
- Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles
Negatively charged immune-modifying microparticles bind to the scavenger receptor MARCO on inflammatory monocytes, resulting in their apoptosis and reduced inflammatory damage in a range of diseases.
- Human TH9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity
Aberrant activation of human TH9 cells may contribute to inflammatory diseases of the skin.
- Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
Barcoding technology enabled measurement of hundreds of cellular proteins from cancer patients with single-cell resolution.
Editors' Choice
- Breathe Easy, But Be Concerned
Exposure to particulate pollution is associated with increased mortality.
- RIG-ging Biomarkers for Therapeutic Response
Hepatic RIG-I is a biomarker for survival and response to interferon-α treatment in hepatocellular carcinoma.
- Releasing the Brake Drives Fear Behavior
Conditioned stimuli inhibit parvalbumin interneurons in the prefrontal cortex, leading to changes in prefrontal oscillations and output that drive conditioned fear behavior.
- Important Job for a Nervous Glucose Transporter
Maintaining normal pancreatic β cell mass and function is regulated by the glucose transporter Glut2 in the nervous system.
Letter
- Comment on “Power of Rare Diseases: Found in Translation”
The recent Perspective entitled “Power of rare diseases: Found in translation” undervalues the contributions of academic research in first-in-human studies.
