15 January 2014
Vol 6, Issue 219
  • Contents

    • Focus

      • Multiplexed Protein Analysis

        Multiplexed protein analysis using an antibody-DNA barcoding approach could accelerate early detection and monitoring of cancer biomarkers in patient samples, as well as unravel pathways leading to therapeutic response or resistance (Ullal et al., this issue).

      • MARCOing Monocytes for Elimination

        Eliminating inflammatory monocytes using microparticles that bind to the MARCO receptor represents a promising strategy to reduce inflammation and injury (Getts et al., this issue).

    • Research Articles

    • Editors' Choice

      • Breathe Easy, But Be Concerned

        Exposure to particulate pollution is associated with increased mortality.

      • Releasing the Brake Drives Fear Behavior

        Conditioned stimuli inhibit parvalbumin interneurons in the prefrontal cortex, leading to changes in prefrontal oscillations and output that drive conditioned fear behavior.

    • Letter

About The Cover

Cover image expansion

ONLINE COVER Skin Inflamed. Lesional skin samples from patients with psoriasis were immunohistochemically stained for interleukin-9 (IL-9) (red). Schlapbach et al. report that, in humans, a subset of T helper cells that produce IL-9, TH9 cells, are mainly tropic for the skin. These cells may function normally to protect against extracellular pathogens, but aberrant activation of these cells may contribute to inflammatory diseases of the skin. [CREDIT: C. SCHLAPBACH/BRIGHAM AND WOMEN'S HOSPITAL, HARVARD MEDICAL SCHOOL/ INSELSPITAL, UNIVERSITY OF BERN]