A Call to Craft

See allHide authors and affiliations

Science Translational Medicine  08 Jan 2014:
Vol. 6, Issue 218, pp. 218fs1
DOI: 10.1126/scitranslmed.3008229


  • Fig. 1. Room to breathe.

    Shown is a decellularized human lung in a custom-designed bioreactor. Turning this protein matrix into a viable organ for transplant will require medical scientists skilled at physical craftsmanship and working environments focused on both investigation and production.



  • Table 1.

    Expertises for training in regenerative medicine. In addition to the basic and biological sciences, engineers will benefit from experience in the rudiments of anatomy, histology, and surgery; a background in custom design, manufacture, and fabrication; and a working understanding of materials and chemical engineering.

    BiologyCell biology
    Cellular mechanics
    Physiology, with lab
    Chemical kinetics, with modeling
    Already at the core of many bioengineering curricula
    Provide an essential foundation for work in regenerative medicine
    Anatomy/histologyGross anatomy, with dissection
    Provide tactile experience working with living tissues and allow firsthand observation of tissue architecure
    Physical and tactile skillsPrinciples of large-scale mammalian cell culture
    Introduction to surgical technique
    Teach the manual techniques required for human-scale organ research
    Technical design and developmentIntroduction to fabrication, with lab
    Bioreactor design, with lab
    Biomedical sensor design, with lab
    Introduction to biomaterials
    Biomaterials processing
    Large-scale cell culture/bioprocessing
    Provide a much-needed technical basis for invention and custom fabrication

Stay Connected to Science Translational Medicine

Navigate This Article