Contents
Vol 6, Issue 218
Contents
Focus
- A Call to Craft
Educational institutions must begin training tissue engineers to think as both biomedical investigators and fabricators.
- Mastering Translational Medicine: Interdisciplinary Education for a New Generation
Graduate-level education in translational medicine will require more than just scientific research.
Research Articles
- A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy
A module-based strategy identified and validated an important diagnostic and therapeutic candidate gene in allergy.
- Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks
In 459 migraine attacks, information provided to patients (from negative to neutral to positive) modified placebo and medication outcomes in a progressive fashion.
- A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects
A light-activated, biodegradable adhesive seals cardiovascular defects in the presence of blood flow and could be useful during minimally invasive surgery.
Editors' Choice
- Nanospherical Scouts on the Lookout for Circulating Tumor Cells
A layer-by-layer magnetic nanoparticle assembly allows rapid and selective detection of circulating cancer cells.
- Oncogene Addiction: How Cells Handle the Habit
A growth hormone–mediated negative feedback loop can explain why CML cells are so addicted to the BCR-ABL oncogene.
- Treating the Brain Through the Gut
Altering the gut microbiota alleviates signs of autism in a mouse model of the disorder.
- Hold the Sugar
Aberrant glucose metabolism may be the cause—not just a consequence—of the malignant phenotype.
- Linking Autoimmunity and Pulmonary Arterial Hypertension
Type I interferon mediates pulmonary arterial hypertension by up-regulating molecules responsible for vasoconstriction, endothelial dysfunction, and smooth muscle cell proliferation.
- A Powerful (Re)Purpose for Genome-Wide Association Studies
A bioinformatics pipeline for GWAS findings identified new uses for existing medications to treat rheumatoid arthritis.