Contents

Contents

• Focus

  • A Call to Craft

    By Micha Sam Brickman Raredon, Laura E. Niklason

    Science Translational Medicine08 Jan 2014 : 218fs1 Full AccessRestricted Access

    Educational institutions must begin training tissue engineers to think as both biomedical investigators and fabricators.

    • Abstract
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  • Mastering Translational Medicine: Interdisciplinary Education for a New Generation

    By Kyle Kurpinski, Terry Johnson, Sanjay Kumar, Tejal Desai, Song Li

    Science Translational Medicine08 Jan 2014 : 218fs2 Full AccessRestricted Access

    Graduate-level education in translational medicine will require more than just scientific research.

    • Abstract
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• Research Articles

  • A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy

    By Sören Bruhn, Yu Fang, Fredrik Barrenäs, Mika Gustafsson, Huan Zhang, Aelita Konstantinell, Andrea Krönke, Birte Sönnichsen, Anne Bresnick, Natalya Dulyaninova, Hui Wang, Yelin Zhao, Jörg Klingelhöfer, Noona Ambartsumian, Mette K. Beck, Colm Nestor, Elsa Bona, Zou Xiang, Mikael Benson

    Science Translational Medicine08 Jan 2014 : 218ra4 Full AccessRestricted Access

    A module-based strategy identified and validated an important diagnostic and therapeutic candidate gene in allergy.

    • Editor's Summary
    • Abstract
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  • Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks

    By Slavenka Kam-Hansen, Moshe Jakubowski, John M. Kelley, Irving Kirsch, David C. Hoaglin, Ted J. Kaptchuk, Rami Burstein

    Science Translational Medicine08 Jan 2014 : 218ra5 Full AccessRestricted Access

    In 459 migraine attacks, information provided to patients (from negative to neutral to positive) modified placebo and medication outcomes in a progressive fashion.

    • Editor's Summary
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  • A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects

    By Nora Lang, Maria J. Pereira, Yuhan Lee, Ingeborg Friehs, Nikolay V. Vasilyev, Eric N. Feins, Klemens Ablasser, Eoin D. O’Cearbhaill, Chenjie Xu, Assunta Fabozzo, Robert Padera, Steve Wasserman, Franz Freudenthal, Lino S. Ferreira, Robert Langer, Jeffrey M. Karp, Pedro J. del Nido

    Science Translational Medicine08 Jan 2014 : 218ra6 Full AccessRestricted Access

    A light-activated, biodegradable adhesive seals cardiovascular defects in the presence of blood flow and could be useful during minimally invasive surgery.

    • Editor's Summary
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• Editors' Choice

  • Nanospherical Scouts on the Lookout for Circulating Tumor Cells

    By Natalie Artzi

    Science Translational Medicine08 Jan 2014 : 218ec4 Full AccessRestricted Access

    A layer-by-layer magnetic nanoparticle assembly allows rapid and selective detection of circulating cancer cells.

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  • Oncogene Addiction: How Cells Handle the Habit

    By Margaret K. Callahan

    Science Translational Medicine08 Jan 2014 : 218ec5 Full AccessRestricted Access

    A growth hormone–mediated negative feedback loop can explain why CML cells are so addicted to the BCR-ABL oncogene.

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  • Treating the Brain Through the Gut

    By Tore Eid

    Science Translational Medicine08 Jan 2014 : 218ec6 Full AccessRestricted Access

    Altering the gut microbiota alleviates signs of autism in a mouse model of the disorder.

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  • Hold the Sugar

    By Cyrus M. Ghajar

    Science Translational Medicine08 Jan 2014 : 218ec7 Full AccessRestricted Access

    Aberrant glucose metabolism may be the cause—not just a consequence—of the malignant phenotype.

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  • Linking Autoimmunity and Pulmonary Arterial Hypertension

    By Adriano R. Tonelli

    Science Translational Medicine08 Jan 2014 : 218ec8 Full AccessRestricted Access

    Type I interferon mediates pulmonary arterial hypertension by up-regulating molecules responsible for vasoconstriction, endothelial dysfunction, and smooth muscle cell proliferation.

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  • A Powerful (Re)Purpose for Genome-Wide Association Studies

    By Deepak Voora

    Science Translational Medicine08 Jan 2014 : 218ec9 Full AccessRestricted Access

    A bioinformatics pipeline for GWAS findings identified new uses for existing medications to treat rheumatoid arthritis.

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