Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice

Amy Brock; Silva Krause; Hu Li; Marek Kowalski; Michael S. Goldberg; James J. Collins; Donald E. Ingber

doi:10.1126/scitranslmed.3007048

Research ArticleCancer

Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice

Amy Brock¹,*,†,
Silva Krause²,*,
Hu Li¹,*,‡,
Marek Kowalski¹,
Michael S. Goldberg³,
James J. Collins¹,⁴ and
Donald E. Ingber¹,²,§

¹Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
²Vascular Biology Program, Boston Children’s Hospital and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
³Dana-Farber Cancer Research Institute, Harvard Medical School, Boston, MA 02115, USA.
⁴Howard Hughes Medical Institute, Boston University, Boston, MA 02115, USA.

↵§Corresponding author. E-mail: don.ingber{at}wyss.harvard.edu

↵* These authors contributed equally to this work.
↵† Present address: Department of Biomedical Engineering and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
↵‡ Present address: Center for Individualized Medicine, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

See allHide authors and affiliations

Science Translational Medicine 01 Jan 2014:
Vol. 6, Issue 217, pp. 217ra2
DOI: 10.1126/scitranslmed.3007048

Amy Brock

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Silva Krause

2Vascular Biology Program, Boston Children’s Hospital and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Hu Li

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Marek Kowalski

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael S. Goldberg

3Dana-Farber Cancer Research Institute, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

James J. Collins

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

4Howard Hughes Medical Institute, Boston University, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Donald E. Ingber

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

2Vascular Biology Program, Boston Children’s Hospital and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: don.ingber@wyss.harvard.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

Log in to view PDF

via AAAS login

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Become an AAAS Member
Activate your Account
Purchase Access to Other Journals in the Science Family
Account Help

As a service to the community, this article is available for free. Existing users log in.

Become a AAAS member
Account help

Log in through your institution

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

View Full Text

Silencing of HoxA1 with nanoparticle siRNA prevented loss of hormone receptor expression, suppressed cell proliferation, and reduced mammary tumor incidence in mice.

Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice

Log in to view PDF

Log in through your institution

Log in through your institution

More options

Science Translational Medicine

Article Tools