Contents

Research Articles

• The Circulating Proteinase Inhibitor α-1 Antitrypsin Regulates Neutrophil Degranulation and Autoimmunity

  By David A. Bergin, Emer P. Reeves, Killian Hurley, Rebecca Wolfe, Ramia Jameel, Sean Fitzgerald, Noel G. McElvaney

  Science Translational Medicine01 Jan 2014 : 217ra1 Full AccessRestricted Access

  α-1 antitrypsin regulates neutrophil-driven autoimmunity.

  • Editor's Summary
  • Abstract
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• Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice

  By Amy Brock, Silva Krause, Hu Li, Marek Kowalski, Michael S. Goldberg, James J. Collins, Donald E. Ingber

  Science Translational Medicine01 Jan 2014 : 217ra2 Full AccessRestricted Access

  Silencing of HoxA1 with nanoparticle siRNA prevented loss of hormone receptor expression, suppressed cell proliferation, and reduced mammary tumor incidence in mice.

  • Editor's Summary
  • Abstract
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• Genetic Engineering of Hematopoiesis for Targeted IFN-α Delivery Inhibits Breast Cancer Progression

  By Giulia Escobar, Davide Moi, Anna Ranghetti, Pinar Ozkal-Baydin, Mario Leonardo Squadrito, Anna Kajaste-Rudnitski, Attilio Bondanza, Bernhard Gentner, Michele De Palma, Roberta Mazzieri, Luigi Naldini

  Science Translational Medicine01 Jan 2014 : 217ra3 Full AccessRestricted Access

  Inhibition of primary and metastatic breast cancer by targeted delivery of interferon-α by tumor-infiltrating monocytes.

  • Editor's Summary
  • Abstract
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