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Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer

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Science Translational Medicine  18 Dec 2013:
Vol. 5, Issue 216, pp. 216ra177
DOI: 10.1126/scitranslmed.3007205

Article Information

vol. 5 no. 216 216ra177

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 31, 2013
  • Accepted for publication November 12, 2013
  • .

Author Information

  1. Hiroyuki Yasuda1,2,*,
  2. Eunyoung Park3,*,
  3. Cai-Hong Yun4,*,
  4. Natasha J. Sng1,
  5. Antonio R. Lucena-Araujo1,
  6. Wee-Lee Yeo1,
  7. Mark S. Huberman1,
  8. David W. Cohen1,,
  9. Sohei Nakayama1,
  10. Kota Ishioka2,
  11. Norihiro Yamaguchi1,
  12. Megan Hanna3,5,
  13. Geoffrey R. Oxnard3,6,
  14. Christopher S. Lathan3,6,
  15. Teresa Moran7,
  16. Lecia V. Sequist7,
  17. Jamie E. Chaft8,
  18. Gregory J. Riely8,
  19. Maria E. Arcila8,
  20. Ross A. Soo9,
  21. Matthew Meyerson3,5,6,
  22. Michael J. Eck3,,
  23. Susumu S. Kobayashi1, and
  24. Daniel B. Costa1,
  1. 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  2. 2Keio University Medical School, Tokyo 160-8582, Japan.
  3. 3Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  4. 4Peking University Health Science Center, Beijing 100191, China.
  5. 5Broad Institute, Massachusetts Institute of Technology and Harvard Medical School, Boston, MA 02142, USA.
  6. 6Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  8. 8Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.
  9. 9Cancer Science Institute of Singapore and National University Cancer Institute, National University of Singapore, Singapore 117599, Singapore.
  1. Corresponding author. E-mail: dbcosta{at}bidmc.harvard.edu (D.B.C.); skobayas{at}bidmc.harvard.edu (S.S.K.); eck{at}red.dfci.harvard.edu (M.J.E.)
  • * These authors contributed equally to this work.

  • Present address: Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.

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