Contents
Vol 5, Issue 216
Contents
Editorial
- New Frontiers for Collaborative Research
The Innovative Medicines Initiative fosters public-private collaborations to accelerate the development of innovative therapies.
Research Articles
- Allelic-Dependent Expression of an Activating Fc Receptor on B Cells Enhances Humoral Immune Responses
Allele-dependent expression of activating FcγRIIc on human B cells enhances humoral immunity.
- CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy
Patients with narcolepsy carry CD4+ T cells that react to peptides from both the sleep-regulating neuropeptide hypocretin and a 2009 H1N1 influenza A protein.
- Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer
Crystal structure and detailed analysis of different EGFR mutants explain why some mutations in exon 20 make lung cancers resistant to EGFR inhibitors and others make them more sensitive.
Review
- Cancer Nanomedicine: From Drug Delivery to Imaging
Nanomedicine has made progress in translating to cancer treatment and imaging, but challenges still remain.
Editors' Choice
- Smoking Moms and Methylation
Placentas of women who smoke during pregnancy display differential methylation patterns relative to nonsmokers.
- Decoding Autism
Two new studies take network-based approaches to unify the complex genetic architecture of autism spectrum disorders.
- Shh, the Baby Mice Are Resting
Prolonged exposure to noise and other stimulation permanently altered blood vessel development in the brains of newborn mice.
- ADEP Leaves No Survivors
A new antibiotic, in conjunction with a conventional antibiotic, was able to eliminate dormant bacteria.
