Contents
Vol 5, Issue 215
Reports
- Metabolic Rates of ATP Transfer Through Creatine Kinase (CK Flux) Predict Clinical Heart Failure Events and Death
Reduced rates of adenosine triphosphate synthesis through myocardial creatine kinase (CK flux) predict adverse clinical events in patients with heart failure.
Letter
Commentary
- Stewardship Practices of U.S. Biobanks
Most U.S. biobanks do not create ongoing relationships with contributors but do practice stewardship over storing and sharing of specimens.
Research Articles
- PD-1– and CTLA-4–Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses
Human T cells that are reversibly inhibited upon contact with antigen protect bystander tissues from immune destruction.
- Dietary Therapy Mitigates Persistent Wake Deficits Caused by Mild Traumatic Brain Injury
Mild traumatic brain injury causes persistent deficits in wakefulness in mice, which are mitigated by a dietary therapy containing branched-chain amino acids.
- CD4+ T Cells from IPEX Patients Convert into Functional and Stable Regulatory T Cells by FOXP3 Gene Transfer
FOXP3 gene transfer in FOXP3-mutated CD4+ T cells is feasible and converts IPEX conventional T cells into regulatory T cells.
Editors' Choice
- Two Proteins, One Stone
Regulation of a single gene mediates recovery from spinal cord injury by optimizing counteracting effectors of axon growth.
- Building Inner Strength
Transdermal drug delivery is enhanced by nanoparticle-reinforced dissolving microneedles.
- A New Kid on the Block
Oncogenic and drug-sensitive rearrangements in the NTRK1 gene are found in some lung cancers.
- Harvesting HLA Region for Multiple Sclerosis Effects
Extensive association analysis of the HLA region established a previously unknown nonclassical allele risk haplotype.
