27 November 2013
Vol 5, Issue 213

About The Cover

Cover image expansion

ONLINE COVER Sensing Drugs in Blood. The ability to continuously sense a drug circulating throughout the body could help doctors personalize therapeutic regimens. In this issue, Ferguson and colleagues describe a microfluidic device that contains drug-specific aptamers (in purple) patterned on gold surfaces. These aptamers bind to drugs (in green) in whole blood, causing an electrochemical readout. Using this biosensor, the authors were able to track a chemotherapeutic, doxorubicin, and an antibiotic, kanamycin, in human blood, as well as in live rodents in real-time. [CREDIT: P. ALLEN/UNIVERSITY OF CALIFORNIA, SANTA BARBARA]