Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

Veerle Rottiers; Susanna Obad; Andreas Petri; Robert McGarrah; Marie W. Lindholm; Joshua C. Black; Sumita Sinha; Robin J. Goody; Matthew S. Lawrence; Andrew S. deLemos; Henrik F. Hansen; Steve Whittaker; Steve Henry; Rohn Brookes; Seyed Hani Najafi-Shoushtari; Raymond T. Chung; Johnathan R. Whetstine; Robert E. Gerszten; Sakari Kauppinen; Anders M. Näär

doi:10.1126/scitranslmed.3006840

Research ArticleMetabolic Syndrome

Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

Veerle Rottiers¹,²,*,
Susanna Obad³,*,
Andreas Petri³,⁴,
Robert McGarrah⁵,⁶,⁷,
Marie W. Lindholm³,
Joshua C. Black¹,⁸,
Sumita Sinha⁵,⁶,
Robin J. Goody⁹,
Matthew S. Lawrence⁹,
Andrew S. deLemos¹⁰,
Henrik F. Hansen³,
Steve Whittaker⁹,
Steve Henry⁹,
Rohn Brookes⁹,
Seyed Hani Najafi-Shoushtari¹,²,¹¹,
Raymond T. Chung¹⁰,
Johnathan R. Whetstine¹,⁸,
Robert E. Gerszten⁵,⁶,
Sakari Kauppinen³,⁴,† and
Anders M. Näär¹,²,†

¹Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.
²Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
³Santaris Pharma, DK-2970 Hørsholm, Denmark.
⁴Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.
⁵Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
⁶Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
⁷Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
⁸Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
⁹RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
¹⁰Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
¹¹Department of Cell and Developmental Biology, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P. O. Box 24144, Doha, Qatar.

↵†Corresponding author. E-mail: naar{at}helix.mgh.harvard.edu (A.M.N.); sk{at}bio.aau.dk (S.K.)

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Translational Medicine 20 Nov 2013:
Vol. 5, Issue 212, pp. 212ra162
DOI: 10.1126/scitranslmed.3006840

Veerle Rottiers

1Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Susanna Obad

3Santaris Pharma, DK-2970 Hørsholm, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andreas Petri

3Santaris Pharma, DK-2970 Hørsholm, Denmark.

4Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robert McGarrah

5Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Marie W. Lindholm

3Santaris Pharma, DK-2970 Hørsholm, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joshua C. Black

1Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

8Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sumita Sinha

5Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robin J. Goody

9RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Matthew S. Lawrence

9RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andrew S. deLemos

10Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Henrik F. Hansen

3Santaris Pharma, DK-2970 Hørsholm, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Steve Whittaker

9RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Steve Henry

9RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rohn Brookes

9RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Seyed Hani Najafi-Shoushtari

1Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

11Department of Cell and Developmental Biology, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P. O. Box 24144, Doha, Qatar.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Raymond T. Chung

10Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Johnathan R. Whetstine

1Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

8Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robert E. Gerszten

5Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sakari Kauppinen

3Santaris Pharma, DK-2970 Hørsholm, Denmark.

4Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: naar@helix.mgh.harvard.edu sk@bio.aau.dk

Anders M. Näär

1Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: naar@helix.mgh.harvard.edu sk@bio.aau.dk

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Long-term treatment of obese, insulin-resistant nonhuman primates with a seed-targeting antimiR oligonucleotide against the microRNA-33 family derepresses hepatic expression of miR-33 targets, increases circulating HDL cholesterol, and has a clean safety profile.

Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools