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Research ArticleMetabolic Syndrome
Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR
- Veerle Rottiers1,2,*,
- Susanna Obad3,*,
- Andreas Petri3,4,
- Robert McGarrah5,6,7,
- Marie W. Lindholm3,
- Joshua C. Black1,8,
- Sumita Sinha5,6,
- Robin J. Goody9,
- Matthew S. Lawrence9,
- Andrew S. deLemos10,
- Henrik F. Hansen3,
- Steve Whittaker9,
- Steve Henry9,
- Rohn Brookes9,
- Seyed Hani Najafi-Shoushtari1,2,11,
- Raymond T. Chung10,
- Johnathan R. Whetstine1,8,
- Robert E. Gerszten5,6,
- Sakari Kauppinen3,4,† and
- Anders M. Näär1,2,†
- 1Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.
- 2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
- 3Santaris Pharma, DK-2970 Hørsholm, Denmark.
- 4Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.
- 5Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
- 6Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
- 7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
- 8Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
- 9RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
- 10Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
- 11Department of Cell and Developmental Biology, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P. O. Box 24144, Doha, Qatar.
- ↵†Corresponding author. E-mail: naar{at}helix.mgh.harvard.edu (A.M.N.); sk{at}bio.aau.dk (S.K.)
-
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Translational Medicine 20 Nov 2013:
Vol. 5, Issue 212, pp. 212ra162
DOI: 10.1126/scitranslmed.3006840
Vol. 5, Issue 212, pp. 212ra162
DOI: 10.1126/scitranslmed.3006840
Veerle Rottiers
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Susanna Obad
Santaris Pharma, DK-2970 Hørsholm, Denmark.
Andreas Petri
Santaris Pharma, DK-2970 Hørsholm, Denmark.Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.
Robert McGarrah
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Marie W. Lindholm
Santaris Pharma, DK-2970 Hørsholm, Denmark.
Joshua C. Black
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Sumita Sinha
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Robin J. Goody
RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
Matthew S. Lawrence
RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
Andrew S. deLemos
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Henrik F. Hansen
Santaris Pharma, DK-2970 Hørsholm, Denmark.
Steve Whittaker
RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
Steve Henry
RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
Rohn Brookes
RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
Seyed Hani Najafi-Shoushtari
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.Department of Cell and Developmental Biology, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P. O. Box 24144, Doha, Qatar.
Raymond T. Chung
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Johnathan R. Whetstine
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Robert E. Gerszten
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Sakari Kauppinen
Santaris Pharma, DK-2970 Hørsholm, Denmark.Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.
Anders M. Näär
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
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