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Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

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Science Translational Medicine  20 Nov 2013:
Vol. 5, Issue 212, pp. 212ra162
DOI: 10.1126/scitranslmed.3006840

Article Information

vol. 5 no. 212 212ra162

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 19, 2013
  • Accepted for publication October 7, 2013
  • .

Author Information

  1. Veerle Rottiers1,2,*,
  2. Susanna Obad3,*,
  3. Andreas Petri3,4,
  4. Robert McGarrah5,6,7,
  5. Marie W. Lindholm3,
  6. Joshua C. Black1,8,
  7. Sumita Sinha5,6,
  8. Robin J. Goody9,
  9. Matthew S. Lawrence9,
  10. Andrew S. deLemos10,
  11. Henrik F. Hansen3,
  12. Steve Whittaker9,
  13. Steve Henry9,
  14. Rohn Brookes9,
  15. Seyed Hani Najafi-Shoushtari1,2,11,
  16. Raymond T. Chung10,
  17. Johnathan R. Whetstine1,8,
  18. Robert E. Gerszten5,6,
  19. Sakari Kauppinen3,4, and
  20. Anders M. Näär1,2,
  1. 1Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.
  2. 2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Santaris Pharma, DK-2970 Hørsholm, Denmark.
  4. 4Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.
  5. 5Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
  6. 6Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  7. 7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  8. 8Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  9. 9RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
  10. 10Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  11. 11Department of Cell and Developmental Biology, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P. O. Box 24144, Doha, Qatar.
  1. Corresponding author. E-mail: naar{at}helix.mgh.harvard.edu (A.M.N.); sk{at}bio.aau.dk (S.K.)
  • * These authors contributed equally to this work.

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