Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma

Andrei P. Drabovich; Apostolos Dimitromanolakis; Punit Saraon; Antoninus Soosaipillai; Ihor Batruch; Brendan Mullen; Keith Jarvi; Eleftherios P. Diamandis

doi:10.1126/scitranslmed.3006260

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Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma

Andrei P. Drabovich¹,
Apostolos Dimitromanolakis²,
Punit Saraon³,
Antoninus Soosaipillai²,
Ihor Batruch²,
Brendan Mullen²,
Keith Jarvi¹,⁴,⁵ and
Eleftherios P. Diamandis¹,²,³,⁶,*

¹Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.
²Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.
³Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
⁴Department of Surgery (Division of Urology), Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5T 3L9, Canada.
⁵Institute of Medical Sciences, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
⁶Department of Clinical Biochemistry, University Health Network, Toronto, Ontario M5G 2C4, Canada.

↵*Corresponding author. E-mail: ediamandis{at}mtsinai.on.ca

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Science Translational Medicine 20 Nov 2013:
Vol. 5, Issue 212, pp. 212ra160
DOI: 10.1126/scitranslmed.3006260

Andrei P. Drabovich

1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

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Apostolos Dimitromanolakis

2Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

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Punit Saraon

3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Antoninus Soosaipillai

2Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

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Ihor Batruch

2Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

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Brendan Mullen

2Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

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Keith Jarvi

1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

4Department of Surgery (Division of Urology), Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5T 3L9, Canada.

5Institute of Medical Sciences, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Eleftherios P. Diamandis

1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

2Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

6Department of Clinical Biochemistry, University Health Network, Toronto, Ontario M5G 2C4, Canada.

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For correspondence: ediamandis@mtsinai.on.ca

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Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma

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