Contents
Vol 5, Issue 212
Review
- Knitting Up the Raveled Sleave of Care
Recent advances in our understanding of molecular clocks highlight their relevance to human physiology and disease.
Focus
- Mechanics Meets Medicine
A new high-throughput measurement technique by Tse et al. (this issue) moves mechanical phenotyping of cells in malignant pleural effusions closer to the clinic.
Research Articles
- Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma
Measurements of seminal plasma proteins ECM1 and TEX101 facilitate the differential diagnosis of azoospermia.
- Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
Introduction of different APOE isoforms modulates Aβ peptide aggregation and neurotoxicity after amyloid deposition in mouse brain.
- Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR
Long-term treatment of obese, insulin-resistant nonhuman primates with a seed-targeting antimiR oligonucleotide against the microRNA-33 family derepresses hepatic expression of miR-33 targets, increases circulating HDL cholesterol, and has a clean safety profile.
- Quantitative Diagnosis of Malignant Pleural Effusions by Single-Cell Mechanophenotyping
Single-cell biophysical properties were used for diagnosing malignant pleural effusions from patients.
Editors' Choice
- Searching for Needles in the T Cell Receptor Haystack
New technology permits high-throughput identification and analysis of specific T cell receptors.
- Removing Salt from the Wound
Central nervous system–specific chloride extrusion enhancers show promise as therapeutics for neuropathic pain.
- Mi Casa No Es Su Casa
Leukemic stem cells that generate AML and CML may reside in distinct niches within the bone marrow microenvironment.
- Nitric Oxide Signaling at the Heart of the Matter
Genetic mutations that affect the nitric oxide pathway and lead to accelerated clotting increase the risk of coronary heart disease.
