Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome

Rajendra Kedlaya; Shreya Veera; Daniel J. Horan; Rachel E. Moss; Ugur M. Ayturk; Christina M. Jacobsen; Margot E. Bowen; Chris Paszty; Matthew L. Warman; Alexander G. Robling

doi:10.1126/scitranslmed.3006627

Research ArticleBONE DISEASE

Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome

Rajendra Kedlaya¹,
Shreya Veera¹,
Daniel J. Horan¹,²,
Rachel E. Moss¹,
Ugur M. Ayturk³,
Christina M. Jacobsen³,
Margot E. Bowen³,
Chris Paszty⁴,
Matthew L. Warman³,⁵,⁶ and
Alexander G. Robling¹,²,⁷,*

¹Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
²Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA.
³Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Boston Children’s Hospital, Boston, MA 02115, USA.
⁴Department of Metabolic Disorders, Amgen Inc., Thousand Oaks, CA 91320, USA.
⁵Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
⁶Howard Hughes Medical Institute, Boston Children’s Hospital, Boston, MA 02115, USA.
⁷Department of Biomedical Engineering, Indiana University–Purdue University at Indianapolis, Indianapolis, IN 46202, USA.

↵*Corresponding author. E-mail: arobling{at}iupui.edu

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Science Translational Medicine 13 Nov 2013:
Vol. 5, Issue 211, pp. 211ra158
DOI: 10.1126/scitranslmed.3006627

Rajendra Kedlaya

1Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Shreya Veera

1Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Daniel J. Horan

1Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA.

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Rachel E. Moss

1Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Ugur M. Ayturk

3Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Boston Children’s Hospital, Boston, MA 02115, USA.

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Christina M. Jacobsen

3Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Boston Children’s Hospital, Boston, MA 02115, USA.

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Margot E. Bowen

3Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Boston Children’s Hospital, Boston, MA 02115, USA.

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Chris Paszty

4Department of Metabolic Disorders, Amgen Inc., Thousand Oaks, CA 91320, USA.

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Matthew L. Warman

3Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Boston Children’s Hospital, Boston, MA 02115, USA.

5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

6Howard Hughes Medical Institute, Boston Children’s Hospital, Boston, MA 02115, USA.

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Alexander G. Robling

1Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA.

7Department of Biomedical Engineering, Indiana University–Purdue University at Indianapolis, Indianapolis, IN 46202, USA.

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For correspondence: arobling@iupui.edu

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Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome

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