Research ArticleObesity

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

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Science Translational Medicine  30 Oct 2013:
Vol. 5, Issue 209, pp. 209ra151
DOI: 10.1126/scitranslmed.3007218

Article Information

vol. 5 no. 209 209ra151

PubMed: 
Print ISSN: 
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History: 
  • Received for publication August 1, 2013
  • Accepted for publication October 11, 2013
  • .

Author Information

  1. Brian Finan1,2,3,*,
  2. Tao Ma3,4,*,
  3. Nickki Ottaway5,
  4. Timo D. Müller1,2,
  5. Kirk M. Habegger5,
  6. Kristy M. Heppner5,
  7. Henriette Kirchner6,
  8. Jenna Holland5,
  9. Jazzminn Hembree5,
  10. Christine Raver5,
  11. Sarah H. Lockie7,
  12. David L. Smiley3,
  13. Vasily Gelfanov3,
  14. Bin Yang3,8,
  15. Susanna Hofmann2,
  16. Dennis Bruemmer9,
  17. Daniel J. Drucker10,
  18. Paul T. Pfluger1,2,5,
  19. Diego Perez-Tilve5,
  20. Jaswant Gidda8,
  21. Louis Vignati8,
  22. Lianshan Zhang8,
  23. Jonathan B. Hauptman11,
  24. Michele Lau11,
  25. Mathieu Brecheisen11,
  26. Sabine Uhles11,
  27. William Riboulet11,
  28. Emmanuelle Hainaut11,
  29. Elena Sebokova11,
  30. Karin Conde-Knape11,
  31. Anish Konkar11,
  32. Richard D. DiMarchi3, and
  33. Matthias H. Tschöp1,2,5,
  1. 1Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg 85764, Germany.
  2. 2Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich 80333, Germany.
  3. 3Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
  4. 4Research Center, Beijing Hanmi Pharmaceutical, Beijing 10131, China.
  5. 5Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA.
  6. 6Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm 17177, Sweden.
  7. 7Department of Physiology, Monash University, Melbourne, Victoria 3800, Australia.
  8. 8Marcadia Biotech, Carmel, IN 46032, USA.
  9. 9Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
  10. 10Department of Medicine, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada.
  11. 11F. Hoffmann–La Roche Ltd., Basel 4070, Switzerland.
  1. Corresponding author. E-mail: rdimarch{at}indiana.edu (R.D.D.); tschoep{at}helmholtz-muenchen.de (M.H.T.)
  • * These authors contributed equally to this work.

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