Research ArticleRheumatoid Arthritis

Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

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Science Translational Medicine  30 Oct 2013:
Vol. 5, Issue 209, pp. 209ra150
DOI: 10.1126/scitranslmed.3006869

Article Information

vol. 5 no. 209 209ra150

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 24, 2013
  • Accepted for publication August 29, 2013
  • .

Author Information

  1. Violeta Romero1,
  2. Justyna Fert-Bober2,
  3. Peter A. Nigrovic3,4,
  4. Erika Darrah1,
  5. Uzma J. Haque1,
  6. David M. Lee3,*,
  7. Jennifer van Eyk2,
  8. Antony Rosen1,5 and
  9. Felipe Andrade1,
  1. 1Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
  2. 2Division of Cardiology, Department of Medicine, Department of Biological Chemistry and the Johns Hopkins Bayview Proteomics Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
  3. 3Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Division of Immunology, Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
  1. Corresponding author. E-mail: andrade{at}jhmi.edu
  • * Present address: Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.

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