Contents
Vol 5, Issue 209
Podcast
- Science Translational Medicine Podcast: 30 October 2013
In this podcast, Chad Mirkin describes how spherical nucleic acid (SNA) nanoparticles can be used for RNAi in glioblastoma.
Editorial
- Can We Measure Autism?
Newly released definitions of autism demonstrate the need for precise diagnoses informed by a patient-information commons.
Focus
- Poking Holes in Rheumatoid Joints
Rheumatoid joints form potentially immunogenic citrullinated proteins through calcium influx and peptidyl arginine deiminase activation.
Research Articles
- Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis
RA-associated hypercitrullination is specifically induced by immune-mediated membrane pore-forming pathways.
- Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans
Compared to best-in-class GLP-1 mono-agonists, unimolecular co-agonists of GLP-1 and GIP with optimized pharmacokinetics enhance glycemic and metabolic benefits in mammals.
- Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma
siRNA-based spherical nucleic acid (SNA) nanoparticle conjugates silence antiapoptosis signaling and impair GBM progression.
- A Genomics-Based Classification of Human Lung Tumors
The pattern of mutations in human lung cancer differs by tumor subtype and is a useful addition to histology for selecting targeted therapy and improving patient survival.
Editors' Choice
- An Aneurysm Model to Help Predict the Unpredictable.
A porcine model of thoracic aortic aneurysm closely recapitulates the clinical hallmarks of this disease.
- One Device to Find Them All
Graphene oxide nanosheets in a microfluidic device integrate both isolation and analysis steps for tracking circulating tumor cells.
- Foiling Inflammatory Bowel Disease
Aluminum enhances intestinal inflammation in a mouse model.
- Out with the New, In with the Old
Computational 21st-century techniques pinpoint tricyclic antidepressants—discovered in the 1950s—as possible cancer therapeutics.
- Pitfalls in Identifying Causal Mutations for Disease
Current methods for determining deleterious mutations, even for known variants in well-established genes, need validation to confirm the phenotypic effects.
