30 October 2013
Vol 5, Issue 209
  • Podcast

  • Editorial

    • Can We Measure Autism?

      Newly released definitions of autism demonstrate the need for precise diagnoses informed by a patient-information commons.

  • Focus

    • Poking Holes in Rheumatoid Joints

      Rheumatoid joints form potentially immunogenic citrullinated proteins through calcium influx and peptidyl arginine deiminase activation.

  • Research Articles

  • Editors' Choice

    • One Device to Find Them All

      Graphene oxide nanosheets in a microfluidic device integrate both isolation and analysis steps for tracking circulating tumor cells.

    • Out with the New, In with the Old

      Computational 21st-century techniques pinpoint tricyclic antidepressants—discovered in the 1950s—as possible cancer therapeutics.

    • Pitfalls in Identifying Causal Mutations for Disease

      Current methods for determining deleterious mutations, even for known variants in well-established genes, need validation to confirm the phenotypic effects.

About The Cover

Cover image expansion

ONLINE COVER Interfering with Cancer. As size reduces, hope grows that one day nanomedicine will be used to treat cancer. Taking the nano field one step further in this direction, Jensen and colleagues combined gold nanoparticles (in yellow) with siRNA (in green) to knock down an oncogene that is overexpressed in human glioma cells. These spherical nucleic acids (SNAs) were able to cross the blood-brain barrier in mice harboring human tumors and block the activity of the gene in a process called RNA interference. [CREDIT: MIRKIN LABORATORY/NORTHWESTERN UNIVERSITY]