30 October 2013
Vol 5, Issue 209

About The Cover

Cover image expansion

ONLINE COVER Interfering with Cancer. As size reduces, hope grows that one day nanomedicine will be used to treat cancer. Taking the nano field one step further in this direction, Jensen and colleagues combined gold nanoparticles (in yellow) with siRNA (in green) to knock down an oncogene that is overexpressed in human glioma cells. These spherical nucleic acids (SNAs) were able to cross the blood-brain barrier in mice harboring human tumors and block the activity of the gene in a process called RNA interference. [CREDIT: MIRKIN LABORATORY/NORTHWESTERN UNIVERSITY]