State of the Art ReviewCardiovascular Disease

Pulmonary Arterial Hypertension: Challenges in Translational Research and a Vision for Change

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Science Translational Medicine  23 Oct 2013:
Vol. 5, Issue 208, pp. 208sr5
DOI: 10.1126/scitranslmed.3005428

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Editor's Summary

Pulmonary arterial hypertension, in which proliferation of vascular cells in the pulmonary circulation occlude blood flow and cause secondary heart failure, cannot be reversed by presently available treatments. The authors of this State of the Art Review argue that a better understanding of the fundamental causes of the disease is needed, including a unified theory of its etiology. In addition, they say, the community should assemble a systematic description of its pathology and natural history, as well as use molecular tools to classify disease. To make progress in translation, the authors call for more focus on dysfunction of the right ventricle and more relevant endpoints such as survival and hemodynamic function in both preclinical and clinical research. Although they concede that none of the available animal models replicates human disease, this disadvantage can be minimized by using multiple animal models.

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