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Research ArticleCancer
Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression
- Raffit Hassan1,*,
- Andrew C. Miller2,
- Elad Sharon3,
- Anish Thomas4,
- James C. Reynolds5,
- Alexander Ling5,
- Robert J. Kreitman1,
- Markku M. Miettinen6,
- Seth M. Steinberg7,
- Daniel H. Fowler8 and
- Ira Pastan1
- 1Laboratory of Molecular Biology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
- 2Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD 20892, USA.
- 3Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, NCI, NIH, Bethesda, MD 20892, USA.
- 4Medical Oncology Branch, CCR, NCI, NIH, Bethesda, MD 20892, USA.
- 5Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, MD 20892, USA.
- 6Laboratory of Pathology, CCR, NCI, NIH, Bethesda, MD 20892, USA.
- 7Biostatistics and Data Management Section, CCR, NCI, NIH, Bethesda, MD 20892, USA.
- 8Experimental Transplantation and Immunology Branch, CCR, NCI, NIH, Bethesda, MD 20892, USA.
- ↵*Corresponding author. E-mail: hassanr{at}mail.nih.gov
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Science Translational Medicine 23 Oct 2013:
Vol. 5, Issue 208, pp. 208ra147
DOI: 10.1126/scitranslmed.3006941
Vol. 5, Issue 208, pp. 208ra147
DOI: 10.1126/scitranslmed.3006941
Raffit Hassan
1Laboratory of Molecular Biology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Andrew C. Miller
2Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD 20892, USA.
Elad Sharon
3Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, NCI, NIH, Bethesda, MD 20892, USA.
Anish Thomas
4Medical Oncology Branch, CCR, NCI, NIH, Bethesda, MD 20892, USA.
James C. Reynolds
5Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, MD 20892, USA.
Alexander Ling
5Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, MD 20892, USA.
Robert J. Kreitman
1Laboratory of Molecular Biology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Markku M. Miettinen
6Laboratory of Pathology, CCR, NCI, NIH, Bethesda, MD 20892, USA.
Seth M. Steinberg
7Biostatistics and Data Management Section, CCR, NCI, NIH, Bethesda, MD 20892, USA.
Daniel H. Fowler
8Experimental Transplantation and Immunology Branch, CCR, NCI, NIH, Bethesda, MD 20892, USA.
Ira Pastan
1Laboratory of Molecular Biology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
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