Contents
Vol 5, Issue 208
State of the Art Review
- Pulmonary Arterial Hypertension: Challenges in Translational Research and a Vision for Change
Successful treatment of pulmonary arterial hypertension requires better understanding of the disease, both clinically and mechanistically.
Focus
- A New Hope for Precision Medicine
The SS1P immunotoxin is combined with immunomodulatory therapy in order to improve its efficacy in human mesothelioma (Hassan et al., this issue).
Research Articles
- Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry
Both genetics and environment contribute to human NK cell diversity.
- Deep Brain Stimulation of the Midbrain Locomotor Region Improves Paretic Hindlimb Function After Spinal Cord Injury in Rats
Stimulating the midbrain improves gait and locomotion in rats with chronic spinal cord injury.
- Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression
In patients with advanced chemotherapy-refractory mesothelioma, treatment with the anti-mesothelin immunotoxin SS1P and immunosuppression with pentostatin and cyclophosphamide resulted in marked and durable tumor regressions.
- Slow-Wave Activity Saturation and Thalamocortical Isolation During Propofol Anesthesia in Humans
In subjects treated with an anesthetic, saturation of slow-wave activity in the EEG indicates the onset of thalamocortical isolation from the external world.
- Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
Antisense oligonucleotides can correct disease-specific phenotypes in cultured motor neurons differentiated from iPSCs derived from ALS patients with a C9ORF72 repeat expansion.
Editors' Choice
- Oxytocin Curbs Cookie Consumption
Intranasal oxytocin administration decreases reward-based food consumption in humans.
- Nanotubes Hunt Down Tumors, Spare Others
A two-step delivery scheme increases efficacy and reduces toxicity in targeted cancer therapy.
- Thinking Before We Act
Analysis of coding variation highlights the challenges of addressing actionable, incidental findings from clinical genomics testing.
