16 October 2013
Vol 5, Issue 207

About The Cover

Cover image expansion

ONLINE COVER Tracking a Killer. In addition to crowds of red and white blood cells, tiny amounts of evidence that proclaim the existence of deadly primary tumors and their metastatic by-products stream through blood vessels. Like detectives who use modern techniques to profile and arrest crime suspects, scientists use noninvasive technologies to detect and characterize tumor-cell DNA (gray) and intact tumor cells (green) that have been shed into the blood stream. In this week’s Perspective, Bidard et al. describe how these biological clues may capture the entire genetic heterogeneity of a given tumor, making it more likely that a deadly cancer may be arrested. [CREDIT: V. ALTOUNIAN/SCIENCE TRANSLATIONAL MEDICINE]