Contents
Vol 5, Issue 207
Perspective
- Going with the Flow: From Circulating Tumor Cells to DNA
Experience gained from the translation of circulating tumor cell detection should help chauffeur circulating tumor DNA into the clinic.
Editorial
- Engineering the Emergence of Stem Cell Therapeutics
The long-awaited translation of stem cell–based therapies to the clinic requires engineering approaches.
Research Articles
- Inhibition of the Cardiomyocyte-Specific Kinase TNNI3K Limits Oxidative Stress, Injury, and Adverse Remodeling in the Ischemic Heart
Blocking the activity of a cardiomyocyte-specific protein kinase with a small-molecule inhibitor reduces oxidative stress, myocyte death, and adverse remodeling in the ischemic heart.
- A Blood-Based Proteomic Classifier for the Molecular Characterization of Pulmonary Nodules
Systems biology and targeted mass spectrometry were combined to develop and validate a blood-based protein classifier for pulmonary nodules.
- mAbs and Ad-Vectored IFN-α Therapy Rescue Ebola-Infected Nonhuman Primates When Administered After the Detection of Viremia and Symptoms
Monoclonal antibodies and adenovirus-vectored IFN-α extend the treatment window for Zaire ebolavirus in macaques.
- Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index
A proteolytically activatable EGFR Probody demonstrates antitumor efficacy while alleviating toxicity.
Editors' Choice
- Looking into the Crystal Ball for Alzheimer’s Disease
Markers may detect early vascular dysfunction in patients at risk for Alzheimer’s disease.
- An Anti-Depressing Discovery for Lung Cancer Treatment
A drug repurposing strategy identifies tricyclic antidepressants as FDA-approved compounds that combat the growth of small cell lung cancer and other neuroendocrine tumors.
- Sense and Sensibility of Insulin Pumps
The insulin pump had a positive impact on type 1 diabetes patients; telling the pump when to stop might do the same.
- Serotonin Gives Oxytocin a Helping Hand
Oxytocin modulates the rewarding effects of social interaction by acting on serotonin release and synaptic plasticity in the nucleus accumbens.
