Research ArticlePrion Disease

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

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Science Translational Medicine  09 Oct 2013:
Vol. 5, Issue 206, pp. 206ra138
DOI: 10.1126/scitranslmed.3006767

Article Information

vol. 5 no. 206 206ra138

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 11, 2013
  • Accepted for publication September 17, 2013
  • .

Author Information

  1. Julie A. Moreno1,
  2. Mark Halliday1,
  3. Colin Molloy1,
  4. Helois Radford1,
  5. Nicholas Verity1,
  6. Jeffrey M. Axten2,
  7. Catharine A. Ortori3,
  8. Anne E. Willis1,
  9. Peter M. Fischer4,
  10. David A. Barrett3 and
  11. Giovanna R. Mallucci1,*
  1. 1MRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.
  2. 2GSK Oncology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  3. 3Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
  4. 4Division of Medicinal Chemistry and Structural Biology, School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
  1. *Corresponding author. E-mail: grm7{at}le.ac.uk

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