Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice | Science Translational Medicine

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Article Information

vol. 5 no. 206 206ra138

DOI:

https://doi.org/10.1126/scitranslmed.3006767

PubMed:

Published By:

American Association for the Advancement of Science

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Online ISSN:

History:

Received for publication June 11, 2013
Accepted for publication September 17, 2013
.

Copyright & Usage:

Copyright © 2013, American Association for the Advancement of Science

Author Information

Julie A. Moreno¹,
Mark Halliday¹,
Colin Molloy¹,
Helois Radford¹,
Nicholas Verity¹,
Jeffrey M. Axten²,
Catharine A. Ortori³,
Anne E. Willis¹,
Peter M. Fischer⁴,
David A. Barrett³ and
Giovanna R. Mallucci¹,*

¹MRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.
²GSK Oncology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
³Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
⁴Division of Medicinal Chemistry and Structural Biology, School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

↵*Corresponding author. E-mail: grm7{at}le.ac.uk

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Science Translational Medicine: 5 (206)

Science Translational Medicine

Vol 5, Issue 206
09 October 2013

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Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

By Julie A. Moreno, Mark Halliday, Colin Molloy, Helois Radford, Nicholas Verity, Jeffrey M. Axten, Catharine A. Ortori, Anne E. Willis, Peter M. Fischer, David A. Barrett, Giovanna R. Mallucci

Science Translational Medicine09 Oct 2013 : 206ra138

Pharmacological inhibition of PERK, the key kinase of the unfolded protein response that mediates translational shutdown, restores protein synthesis in prion-infected mice, thus preventing neurodegeneration and clinical disease.

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Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

By Julie A. Moreno, Mark Halliday, Colin Molloy, Helois Radford, Nicholas Verity, Jeffrey M. Axten, Catharine A. Ortori, Anne E. Willis, Peter M. Fischer, David A. Barrett, Giovanna R. Mallucci

Science Translational Medicine09 Oct 2013 : 206ra138

Pharmacological inhibition of PERK, the key kinase of the unfolded protein response that mediates translational shutdown, restores protein synthesis in prion-infected mice, thus preventing neurodegeneration and clinical disease.

Supplementary Materials
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