Contents
Vol 5, Issue 205
Contents
Research Articles
- Sulfate Metabolites Provide an Intracellular Pool for Resveratrol Generation and Induce Autophagy with Senescence
Biologically active concentrations of resveratrol can be generated intracellularly after uptake of the major human sulfate metabolites by selected cells.
- A Human Type 5 Adenovirus–Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity
An adenovirus-based TB vaccine elicits T cell immunogenicity despite preexisting anti-AdHu5 immunity in people.
- Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy
An in vitro system can determine the pharmacokinetic drivers of antimalarial drug pharmacodynamics, leading to more rationally developed new drug candidates.
- Peripheral Blood Mononuclear Cell Gene Expression Profiles Predict Poor Outcome in Idiopathic Pulmonary Fibrosis
Genome-scale transcriptomic profiling of peripheral blood mononuclear cells from patients with idiopathic pulmonary fibrosis reveals that decreased expression of CD28, ICOS, LCK, and ITK predicts mortality.
Review
- High-Throughput Methods for Combinatorial Drug Discovery
Combinatorial drug discovery will rely on new approaches to analyzing highly dimensional data resources.
Editors' Choice
- Sticking with the Pattern for a Safer Glue
Surface micropatterning and reactive chemistry are used to develop adhesive materials with adequate adhesion and reduced toxicity.
- Neutrophils Block Bacterial Flood in Gut Infection
Neutrophils form a protective cast around commensal bacteria to limit mucosal exposure during intestinal infections.
- Length Matters
Reduced transcription of very long genes depends on the activity of topoisomerase enzymes that have been implicated in autism spectrum disorders.
- B Lymphocytes: Adding Insult to Injury After Myocardial Infarction
Pathologic remodeling of the heart after myocardial infarction is mediated by B2 lymphocyte secretion of CCL-7, leading to recruitment of a harmful type of monocyte.
