Contents
Vol 5, Issue 203
Erratum
Perspective
- All Signals Lost
Bacterial histidine kinase inhibitors that globally block bacterial signaling may offer a new offensive against antibiotic resistance.
Research Articles
- Postnatal Soluble FGFR3 Therapy Rescues Achondroplasia Symptoms and Restores Bone Growth in Mice
A recombinant soluble fibroblast growth factor receptor 3 (FGFR3) restored normal skeletal growth and prevented disease-related complications in a mouse model of achondroplasia.
- MHC Class I–Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia
Immunity against phosphopeptide antigens lacking in leukemia patients can be restored with stem cell transplantation.
- A Host-Based RT-PCR Gene Expression Signature to Identify Acute Respiratory Viral Infection
To improve the diagnosis of respiratory viral infection, a multiplex RT-PCR assay based on the host response was derived from experimentally infected subjects and validated in patients with febrile illness.
- Angiopoietin-1 Guides Directional Angiogenesis Through Integrin αvβ5 Signaling for Recovery of Ischemic Retinopathy
Angiopoietin-1 supplementation stimulates guided angiogenesis and promotes the formation of a healthy vascular network in a mouse model of ischemic retinopathy.
Editors' Choice
- A Step Closer to Therapy for Leaky Vessels.
Vascular permeability can be regulated by specifically blocking a microRNA that targets VE-cadherin.
- Forging New Approaches to Stem Cell Tracking
Neural stem cells were tracked in the mouse brain using nanoparticles and magnetic resonance imaging.
- Zoning In on Obesity
Zonulin may be a useful marker of gut microbiota-associated systemic micro-inflammation in obese patients.
- A New Achilles Heel for Prostate Cancer
A gain-of-function mutation promotes dihydrotestosterone synthesis in castration-resistant prostate cancer.
- Finnish Bottlenecks Enrich Risk-Conferring Deletion of TOP3β
Mapping of copy number variation in Finnish isolates identifies deletions of TOP3β, a putative component of neuronal mRNA translation, as a risk factor for schizophrenia and cognitive difficulties.
