Contents
Vol 5, Issue 202
Editorial
- From Dissecting Cadavers to Dissecting Genomes
Only when medical education mandates that students annotate whole-genome sequences will future physicians be capable of rendering routine genomic medicine.
Research Articles
- Vaccination with Leishmania Hemoglobin Receptor–Encoding DNA Protects Against Visceral Leishmaniasis
Hemoglobin receptor is a vaccine candidate against visceral leishmaniasis.
- A Molecular Signature Predictive of Indolent Prostate Cancer
A three-gene panel derived from mechanistic models of cell senescence predicts outcome of low Gleason score prostate tumors.
- Down-Regulation of Autophagy-Related Protein 5 (ATG5) Contributes to the Pathogenesis of Early-Stage Cutaneous Melanoma
Down-regulation of autophagy-related protein 5 decreases autophagy and contributes to tumorigenesis in human melanoma cells and patients’ tumors.
Editors' Choice
- BAT Burns Fat? Cool.
Cold exposure activates brown adipose tissue in adult humans, increasing nonshivering thermogenesis and energy expenditure while decreasing fat mass.
- Co-opting a Tumor Predator to Provide Life Support
Tumor cells acquire resistance to anti-VEGF therapy by mobilizing immune cells through an IL-17–mediated paracrine signaling network.
- Implantable Lanterns for Cancer Therapy
Implantable illumination devices enable selective thermal and drug therapy of deep tumors.
- The Virtue of Intolerance
Ordering genes based on genetic variation at the population level helps to prioritize mutations that underlie human disease.
