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Research ArticleDown Syndrome
Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model
- Ishita Das1,
- Joo-Min Park2,3,
- Jung H. Shin4,
- Soo Kyeong Jeon2,
- Hernan Lorenzi1,*,
- David J. Linden2,
- Paul F. Worley2 and
- Roger H. Reeves1,†
- 1Department of Physiology and Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 3Department of Physiology, Jeju National University School of Medicine, Jeju 690-756, South Korea.
- 4Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20857, USA.
- ↵†Corresponding author. E-mail: rreeves{at}jhmi.edu
-
↵* Present address: The J. Craig Venter Institute, Rockville, MD 20850, USA.
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Science Translational Medicine 04 Sep 2013:
Vol. 5, Issue 201, pp. 201ra120
DOI: 10.1126/scitranslmed.3005983
Vol. 5, Issue 201, pp. 201ra120
DOI: 10.1126/scitranslmed.3005983
Ishita Das
1Department of Physiology and Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Joo-Min Park
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3Department of Physiology, Jeju National University School of Medicine, Jeju 690-756, South Korea.
Jung H. Shin
4Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20857, USA.
Soo Kyeong Jeon
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Hernan Lorenzi
1Department of Physiology and Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
David J. Linden
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Paul F. Worley
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Roger H. Reeves
1Department of Physiology and Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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