Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells | Science Translational Medicine

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Article Information

vol. 5 no. 200 200ra116

DOI:

https://doi.org/10.1126/scitranslmed.3006504

PubMed:

Published By:

American Association for the Advancement of Science

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Online ISSN:

History:

Received for publication May 3, 2013
Accepted for publication June 19, 2013
.

Copyright & Usage:

Copyright © 2013, American Association for the Advancement of Science

Author Information

Stefani Spranger¹,*,
Robbert M. Spaapen¹,*,
Yuanyuan Zha²,
Jason Williams¹,
Yuru Meng¹,
Thanh T. Ha¹ and
Thomas F. Gajewski¹,²,†

¹Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.
²Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.

↵†Corresponding author. E-mail: tgajewsk{at}medicine.bsd.uchicago.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine: 5 (200)

Science Translational Medicine

Vol 5, Issue 200
28 August 2013

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Up-Regulation of PD-L1, IDO, and T_regs in the Melanoma Tumor Microenvironment Is Driven by CD8⁺ T Cells

By Stefani Spranger, Robbert M. Spaapen, Yuanyuan Zha, Jason Williams, Yuru Meng, Thanh T. Ha, Thomas F. Gajewski

Science Translational Medicine28 Aug 2013 : 200ra116

CD8⁺ T cells induce immunosuppressive mechanisms in the tumor microenvironment.

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Up-Regulation of PD-L1, IDO, and T_regs in the Melanoma Tumor Microenvironment Is Driven by CD8⁺ T Cells

By Stefani Spranger, Robbert M. Spaapen, Yuanyuan Zha, Jason Williams, Yuru Meng, Thanh T. Ha, Thomas F. Gajewski

Science Translational Medicine28 Aug 2013 : 200ra116

CD8⁺ T cells induce immunosuppressive mechanisms in the tumor microenvironment.

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