Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells | Science Translational Medicine

Skip to main content

ScienceMag.org

Article Information

vol. 5 no. 200 200ra116

DOI:

https://doi.org/10.1126/scitranslmed.3006504

PubMed:

Published By:

American Association for the Advancement of Science

Print ISSN:

Online ISSN:

History:

Received for publication May 3, 2013
Accepted for publication June 19, 2013
.

Copyright & Usage:

Copyright © 2013, American Association for the Advancement of Science

Author Information

Stefani Spranger¹,*,
Robbert M. Spaapen¹,*,
Yuanyuan Zha²,
Jason Williams¹,
Yuru Meng¹,
Thanh T. Ha¹ and
Thomas F. Gajewski¹,²,†

¹Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.
²Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.

↵†Corresponding author. E-mail: tgajewsk{at}medicine.bsd.uchicago.edu

↵* These authors contributed equally to this work.

Altmetric

Article usage

Article usage: August 2013 to October 2019

	Abstract	Full	Pdf
Aug 2013	5314	151	404
Sep 2013	5293	286	633
Oct 2013	1973	156	318
Nov 2013	1222	90	178
Dec 2013	855	59	118
Jan 2014	898	80	154
Feb 2014	726	66	125
Mar 2014	732	64	144
Apr 2014	603	60	99
May 2014	627	58	131
Jun 2014	485	58	103
Jul 2014	414	40	91
Aug 2014	361	45	88
Sep 2014	322	64	80
Oct 2014	333	83	76
Nov 2014	374	68	64
Dec 2014	316	105	87
Jan 2015	564	142	144
Feb 2015	398	81	90
Mar 2015	456	74	81
Apr 2015	459	104	128
May 2015	385	80	109
Jun 2015	508	99	119
Jul 2015	376	68	137
Aug 2015	86	45	97
Sep 2015	108	60	106
Oct 2015	69	62	114
Nov 2015	113	56	130
Dec 2015	151	56	103
Jan 2016	517	54	128
Feb 2016	649	84	162
Mar 2016	600	60	166
Apr 2016	492	48	133
May 2016	462	51	110
Jun 2016	537	47	113
Jul 2016	599	59	122
Aug 2016	575	45	107
Sep 2016	589	37	108
Oct 2016	594	44	108
Nov 2016	640	53	122
Dec 2016	455	27	68
Jan 2017	481	34	64
Feb 2017	392	41	88
Mar 2017	501	56	107
Apr 2017	399	39	93
May 2017	405	47	80
Jun 2017	496	31	120
Jul 2017	444	32	73
Aug 2017	470	31	64
Sep 2017	509	38	76
Oct 2017	674	55	101
Nov 2017	471	70	131
Dec 2017	294	47	68
Jan 2018	412	42	95
Feb 2018	308	49	80
Mar 2018	313	33	82
Apr 2018	381	34	73
May 2018	345	45	70
Jun 2018	338	45	85
Jul 2018	457	55	70
Aug 2018	155	86	78
Sep 2018	135	76	57
Oct 2018	182	61	91
Nov 2018	139	120	79
Dec 2018	172	76	51
Jan 2019	282	110	71
Feb 2019	161	87	51
Mar 2019	139	111	76
Apr 2019	129	102	62
May 2019	139	105	77
Jun 2019	114	78	48
Jul 2019	141	62	48
Aug 2019	130	56	51
Sep 2019	100	52	35
Oct 2019	39	35	17

Science Translational Medicine: 5 (200)

Science Translational Medicine

Vol 5, Issue 200
28 August 2013

Table of Contents

Article Tools

Email

Thank you for your interest in spreading the word about Science Translational Medicine.
NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email

Your Name

Send To
Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

Message Subject (Your Name) has forwarded a page to you from Science Translational Medicine

Message Body (Your Name) thought you would like to see this page from the Science Translational Medicine web site.

Your Personal Message
Download Powerpoint
Print
Save to my folders

Log In with your AAAS Login
Alerts

Please log in to add an alert for this article.

Log In with your AAAS Login

Sign In to Email Alerts with your Email Address
Email
Citation tools
Up-Regulation of PD-L1, IDO, and T_regs in the Melanoma Tumor Microenvironment Is Driven by CD8⁺ T Cells

By Stefani Spranger, Robbert M. Spaapen, Yuanyuan Zha, Jason Williams, Yuru Meng, Thanh T. Ha, Thomas F. Gajewski

Science Translational Medicine28 Aug 2013 : 200ra116

CD8⁺ T cells induce immunosuppressive mechanisms in the tumor microenvironment.

Supplementary Materials

Citation Manager Formats

BibTeX

Bookends

EasyBib

EndNote (tagged)

EndNote 8 (xml)

Medlars

Mendeley

Papers

RefWorks Tagged

Ref Manager

RIS

Zotero
Share
Up-Regulation of PD-L1, IDO, and T_regs in the Melanoma Tumor Microenvironment Is Driven by CD8⁺ T Cells

By Stefani Spranger, Robbert M. Spaapen, Yuanyuan Zha, Jason Williams, Yuru Meng, Thanh T. Ha, Thomas F. Gajewski

Science Translational Medicine28 Aug 2013 : 200ra116

CD8⁺ T cells induce immunosuppressive mechanisms in the tumor microenvironment.

Supplementary Materials
Share This Article:

Citing Articles in: