Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation

Beate M. Lichtenberger; Peter A. Gerber; Martin Holcmann; Bettina A. Buhren; Nicole Amberg; Viktoria Smolle; Holger Schrumpf; Edwin Boelke; Parinaz Ansari; Colin Mackenzie; Andreas Wollenberg; Andreas Kislat; Jens W. Fischer; Katharina Röck; Jürgen Harder; Jens M. Schröder; Bernhard Homey; Maria Sibilia

doi:10.1126/scitranslmed.3005886

Research ArticleCancer

Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation

Beate M. Lichtenberger¹,*,†,
Peter A. Gerber²,*,
Martin Holcmann¹,*,
Bettina A. Buhren²,
Nicole Amberg¹,
Viktoria Smolle¹,
Holger Schrumpf²,
Edwin Boelke³,
Parinaz Ansari²,
Colin Mackenzie⁴,
Andreas Wollenberg⁵,
Andreas Kislat²,
Jens W. Fischer⁶,
Katharina Röck⁶,
Jürgen Harder⁷,
Jens M. Schröder⁷,
Bernhard Homey²,*,‡ and
Maria Sibilia¹,*,‡

¹Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.
²Department of Dermatology, University of Duesseldorf, 40225 Duesseldorf, Germany.
³Department of Radiation-Oncology, University of Duesseldorf, 40225 Duesseldorf, Germany.
⁴Institute of Medical Microbiology, Medical Faculty, University of Duesseldorf, 40225 Duesseldorf, Germany.
⁵Department of Dermatology and Allergy, Ludwig-Maximilian University, 80337 Munich, Germany.
⁶Institute of Pharmacology and Clinical Pharmacology, Heinrich-Heine-University Düsseldorf, 40225 Duesseldorf, Germany.
⁷Department of Dermatology, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

↵‡Corresponding author. E-mail: maria.sibilia{at}meduniwien.ac.at (M.S.); bernhard.homey{at}uni-duesseldorf.de (B.H.)

↵* These authors contributed equally to this work.
↵† Present address: Centre for Stem Cells and Regenerative Medicine, Division of Genetics and Molecular Medicine, King’s College London, London SE1 9RT, UK.

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Science Translational Medicine 21 Aug 2013:
Vol. 5, Issue 199, pp. 199ra111
DOI: 10.1126/scitranslmed.3005886

Beate M. Lichtenberger

1Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.

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Peter A. Gerber

2Department of Dermatology, University of Duesseldorf, 40225 Duesseldorf, Germany.

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Martin Holcmann

1Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.

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Bettina A. Buhren

2Department of Dermatology, University of Duesseldorf, 40225 Duesseldorf, Germany.

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Nicole Amberg

1Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.

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Viktoria Smolle

1Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.

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Holger Schrumpf

2Department of Dermatology, University of Duesseldorf, 40225 Duesseldorf, Germany.

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Edwin Boelke

3Department of Radiation-Oncology, University of Duesseldorf, 40225 Duesseldorf, Germany.

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Parinaz Ansari

2Department of Dermatology, University of Duesseldorf, 40225 Duesseldorf, Germany.

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Colin Mackenzie

4Institute of Medical Microbiology, Medical Faculty, University of Duesseldorf, 40225 Duesseldorf, Germany.

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Andreas Wollenberg

5Department of Dermatology and Allergy, Ludwig-Maximilian University, 80337 Munich, Germany.

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Andreas Kislat

2Department of Dermatology, University of Duesseldorf, 40225 Duesseldorf, Germany.

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Jens W. Fischer

6Institute of Pharmacology and Clinical Pharmacology, Heinrich-Heine-University Düsseldorf, 40225 Duesseldorf, Germany.

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Katharina Röck

6Institute of Pharmacology and Clinical Pharmacology, Heinrich-Heine-University Düsseldorf, 40225 Duesseldorf, Germany.

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Jürgen Harder

7Department of Dermatology, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

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Jens M. Schröder

7Department of Dermatology, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

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Bernhard Homey

2Department of Dermatology, University of Duesseldorf, 40225 Duesseldorf, Germany.

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For correspondence: maria.sibilia@meduniwien.ac.at bernhard.homey@uni-duesseldorf.de

Maria Sibilia

1Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.

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For correspondence: maria.sibilia@meduniwien.ac.at bernhard.homey@uni-duesseldorf.de

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Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation

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