Contents
Vol 5, Issue 199
Contents
Editorial
- Research for Universal Health Coverage
The 2013 World Health Report argues that universal health coverage cannot be achieved without funding basic and applied health research.
Focus
- Skinflammation and Drug Toxicity—A Delicate Balance
Loss of epidermal growth factor receptor function in keratinocytes triggers an acneiform rash through activation of innate and adaptive immune defense mechanisms.
Research Articles
- Genetic Ablation of Epidermal EGFR Reveals the Dynamic Origin of Adverse Effects of Anti-EGFR Therapy
Epidermal EGFR ablation causes a localized cutaneous rash and a systemic inflammatory syndrome.
- Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation
Epidermal EGFR regulates skin inflammation and contributes to skin barrier function and host defense.
- Improved Rodent Maternal Metabolism But Reduced Intrauterine Growth After Vertical Sleeve Gastrectomy
Despite improved rodent maternal metabolism after vertical sleeve gastrectomy, offspring of dams after surgery show intrauterine growth restriction.
- Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail
Ebola virus–infected macaques were successfully treated with a cocktail of monoclonals manufactured in plants.
Editors' Choice
- XIST-ing Down Syndrome
Harnessing the cell’s ability to silence X chromosomes yields a promising tool to inhibit the extra chromosome 21 in human induced pluripotent stem cells from Down syndrome patients.
- Bromodomains—Placing BETs on Chromatin in Heart Failure?
BET family proteins are crucial mediators of the genetic reprogramming leading to experimental heart failure.
- Good and Bad Bacteria Fight for Iron in the Gut
A probiotic strain, E. coli Nissle 1917, uses multiple iron transporters to outcompete Salmonella in the inflamed gut.
