Contents

Contents

• Editorial

  • Regulating Genomics: Time for a Broader Vision

    By Effy Vayena, Barbara Prainsack

    Science Translational Medicine14 Aug 2013 : 198ed12 Full AccessRestricted Access

    Regulators must consider the potential benefits of using genomic information to advance clinical medicine.

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• Focus

  • Making Waves in Consciousness Research

    By Nicholas D. Schiff

    Science Translational Medicine14 Aug 2013 : 198fs32 Full AccessRestricted Access

    A new strategy for quantifying consciousness may have broad applications in the clinic and the lab.

    • Abstract
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• Research Articles

  • A Theoretically Based Index of Consciousness Independent of Sensory Processing and Behavior

    By Adenauer G. Casali, Olivia Gosseries, Mario Rosanova, Mélanie Boly, Simone Sarasso, Karina R. Casali, Silvia Casarotto, Marie-Aurélie Bruno, Steven Laureys, Giulio Tononi, Marcello Massimini

    Science Translational Medicine14 Aug 2013 : 198ra105 Full AccessRestricted Access

    A theory-derived index of consciousness, which quantifies the complexity of the brain’s response to a stimulus, measures the level of consciousness in awake, sleeping, anesthetized, and brain-damaged subjects.

    • Editor's Summary
    • Abstract
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  • Fetal Urinary Peptides to Predict Postnatal Outcome of Renal Disease in Fetuses with Posterior Urethral Valves (PUV)

    By Julie Klein, Chrystelle Lacroix, Cécile Caubet, Justyna Siwy, Petra Zürbig, Mohammed Dakna, Françoise Muller, Benjamin Breuil, Angelique Stalmach, William Mullen, Harald Mischak, Flavio Bandin, Bernard Monsarrat, Jean-Loup Bascands, Stéphane Decramer, Joost P. Schanstra

    Science Translational Medicine14 Aug 2013 : 198ra106 Full AccessRestricted Access

    Peptides found in fetal urine predict end-stage renal disease in patients with a congenital abnormality of the kidney and urinary tract.

    • Editor's Summary
    • Abstract
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  • Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis

    By Matthew S. Miller, Thomas J. Gardner, Florian Krammer, Lauren C. Aguado, Domenico Tortorella, Christopher F. Basler, Peter Palese

    Science Translational Medicine14 Aug 2013 : 198ra107 Full AccessRestricted Access

    Antigenic variation promotes neutralizing antibodies to both seasonal and pandemic influenza A strains in humans.

    • Editor's Summary
    • Abstract
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  • Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-¹³C]Pyruvate

    By Sarah J. Nelson, John Kurhanewicz, Daniel B. Vigneron, Peder E. Z. Larson, Andrea L. Harzstark, Marcus Ferrone, Mark van Criekinge, Jose W. Chang, Robert Bok, Ilwoo Park, Galen Reed, Lucas Carvajal, Eric J. Small, Pamela Munster, Vivian K. Weinberg, Jan Henrik Ardenkjaer-Larsen, Albert P. Chen, Ralph E. Hurd, Liv-Ingrid Odegardstuen, Fraser J. Robb, James Tropp, Jonathan A. Murray

    Science Translational Medicine14 Aug 2013 : 198ra108 Full AccessRestricted Access

    Metabolic imaging with hyperpolarized pyruvate was used to safely and noninvasively visualize prostate tumors in patients.

    • Editor's Summary
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• Editors' Choice

  • A Fat Chance for Antidepressants

    By Christopher Gregg

    Science Translational Medicine14 Aug 2013 : 198ec133 Full AccessRestricted Access

    Antidepressants inhibit acid sphingomyelinase to influence neurogenesis and depression-like behaviors.

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  • A Primate Model for Autism

    By Egle Bytautiene

    Science Translational Medicine14 Aug 2013 : 198ec134 Full AccessRestricted Access

    Pregnant macaques given human autoantibodies against fetal brain proteins results in autism-like behavior patterns and increased brain volume in the offspring.

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  • Drugs and Bugs

    By Deepak Voora

    Science Translational Medicine14 Aug 2013 : 198ec135 Full AccessRestricted Access

    Knowing how a specific bacterial strain inactivates the cardiac drug digoxin can pinpoint new biomarkers for tailoring therapy.

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  • A New Drug on the Block

    By Anandi N. Sheth

    Science Translational Medicine14 Aug 2013 : 198ec136 Full AccessRestricted Access

    A new synthetic compound with a different mechanism of action from traditional tuberculosis (TB) drugs is safe and effective in a mouse model of TB.

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  • Casting Infection as Cancer’s Best Friend

    By Yevgeniya A. Nusinovich

    Science Translational Medicine14 Aug 2013 : 198ec137 Full AccessRestricted Access

    Infection in cancer patients may increase the risk of metastasis.

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