Research ArticleCancer

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

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Science Translational Medicine  07 Aug 2013:
Vol. 5, Issue 197, pp. 197ra101
DOI: 10.1126/scitranslmed.3006086

Article Information

vol. 5 no. 197 197ra101

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History: 
  • Received for publication March 7, 2013
  • Accepted for publication July 5, 2013
  • .

Author Information

  1. Song Ling Poon1,2,*,
  2. See-Tong Pang3,*,,
  3. John R. McPherson2,*,
  4. Willie Yu1,2,4,
  5. Kie Kyon Huang2,5,
  6. Peiyong Guan6,
  7. Wen-Hui Weng7,
  8. Ee Yan Siew1,2,
  9. Yujing Liu2,8,
  10. Hong Lee Heng1,2,
  11. Soo Ching Chong1,2,
  12. Anna Gan1,2,
  13. Su Ting Tay9,
  14. Weng Khong Lim1,2,
  15. Ioana Cutcutache2,
  16. Dachuan Huang1,2,
  17. Lian Dee Ler1,2,4,
  18. Maarja-Liisa Nairismägi1,2,
  19. Ming Hui Lee9,
  20. Ying-Hsu Chang3,
  21. Kai-Jie Yu3,
  22. Waraporn Chan-on1,2,
  23. Bin-Kui Li10,
  24. Yun-Fei Yuan11,
  25. Chao-Nan Qian11,
  26. Kwai-Fong Ng12,
  27. Ching-Fang Wu13,
  28. Cheng-Lung Hsu14,
  29. Ralph M. Bunte15,
  30. Michael R. Stratton16,
  31. P. Andrew Futreal17,
  32. Wing-Kin Sung6,18,
  33. Cheng-Keng Chuang3,
  34. Choon Kiat Ong1,2,
  35. Steven G. Rozen2,19,,
  36. Patrick Tan2,5,9,18, and
  37. Bin Tean Teh1,2,5,
  1. 1NCCS-VARI Translational Research Laboratory, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  2. 2Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
  3. 3Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Linkou; School of Medicine, Chang Gung University, 5, Fusing Street, Gueishan Township, Taoyuan County 333, Taiwan.
  4. 4National University of Singapore Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, Singapore 117456, Singapore.
  5. 5Cancer Science Institute of Singapore, National University of Singapore, Centre for Life Sciences, 28 Medical Drive, Singapore 117456, Singapore.
  6. 6School of Computing, National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077, Singapore.
  7. 7Department of Chemical Engineering and Biotechnology, Graduate Institute of Biotechnology, National Taipei University of Technology, 1, Section 3, Chung-hsiao East Road, Taipei 10608, Taiwan.
  8. 8Computational and Systems Biology, Singapore-MIT Alliance, National University of Singapore, Singapore 119077, Singapore.
  9. 9Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  10. 10Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China.
  11. 11State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China.
  12. 12Department of Pathology, Chang Gung Memorial Hospital, Linkou; School of Medicine Chang Gung University, Taoyuan County 333, Taiwan.
  13. 13Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan County 333, Taiwan.
  14. 14Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan County 333, Taiwan.
  15. 15Office of Research, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.
  16. 16Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
  17. 17Genomic Medicine, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1954, Houston, TX 77030, USA.
  18. 18Genome Institute of Singapore, 60 Biopolis Street Genome, Singapore 138672, Singapore.
  19. 19Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
  1. Corresponding author. E-mail: teh.bin.tean{at}singhealth.com.sg (B.T.T.); gmstanp{at}duke-nus.edu.sg (P.T.); steve.rozen{at}duke-nus.edu.sg (S.G.R.); jacobpang{at}adm.cgmh.org.tw (S.-T.P.)
  • * These authors contributed equally to this work.

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